The Clinical Study Of The Capsule Of Rhodiola On Patients After Percutaneous Coronary Intervention

Objective:To explore the effect of the capsule of Rhodiola on patients with acute coronary syndrome after percutaneous coronary intervention (PCI),to evaluate the function of the capsule of Rhodiola on patients after percutaneous coronary intervention. To explore the possible mechanism of myocardial protection of Rhodiola capsules on patients after percutaneous coronary intervention by observing the symptoms of myocardial ischemia, blood lipids, serum levels of inflammatory factors and adiponectin factors.Methods:Sixtey-four patients with acute coronary syndrome (ACS) were selected from December2010to September2011in Wuhan General Hospital of Guangzhou Military, underwent cornory stent implantation. According to the random number table, it was randomly divided into two groups, treatment group (34cases) and control group (30ones). There were not significantly different of clinical conditions (Age, gender, smoking, hypertension, hyperlipidemia and etc) between two groups. Percutaneous coronary intervention:the arterial sheath (6F-7F) was placed in the femoral artery after the success of puncture, inject the catheter into the left and right coronary artery along the guide wire, then indentify the stenosis of the coronary by multi-position projection with Iobitridol Injection, the guiding catheter were in place along the guide wire, then inject into a0.014"guide wire to the distal lesion, and place a balloon to the stenosis, inflate the balloon by6-12ATM, expand the stent in the lesion at6-15ATM, Coronary angiography shows no stenosis, and stent is in good adherence, then remove the balloon and catheter. All patients were given conventional medicine(anti-platelet lipid-lowering and dilating coronary drug), treatment group were administrated with capsules of Rhodiola0.56g plus24hours of preoperative and postoperative, PO, three times a day, ninety days. The serum samples of the patients were collected in the preoperative and postoperative1day,1month,3month, which were determined the concentration of PCI pre-and postoperative serum lipids、 adiponectin and inflammatory factors, observe the chest tightness, chest pain frequency and times and other clinical symptoms at the period of three months.The research data were analyzed by SPSS16.0software, firstly, conduct the normality and homogeneity of variance test, normal distributed data as mean±standard deviation (x±s). Comparison between groups, use analysis of variance, normal variance distribution and repeated measurement data. The comparisons of group inside were by the Bonferroni method (Epsilon<0.7, without LSD method). The accountant data between the two groups were compared with the x2test, when it is t less than five, it is used by Fisher’s exact probability test.Results:1、 The serum TNF-α of treatment patients before PCI is262.33 ±69.35μg/mL, rose to347.48±55.07μg/mL after1day post-PCI, declined to25.76±14.48μg/mL after1month post-PCI, finally decreased to10.60±6.55μg/mL after3months post-PCI, pairwise comparisons in the treatment group are significant differences (P<0.01); The serum TNF-α of the control patients before PCI is255.63±67.97μg/mL, increased to389.71±6.15μg/mL after1day post-PCI, declined to34.96±18.27μg/mL after1month post-PCI, eventually declined to10.60±6.55μg/mL after3months post-PCI, pairwise comparisons in the control group are significant differences(P<0.01). Between the two groups, the preoperative serum TNF-a is no significant difference, but whose (after1day post-PCI、 after1month post-PCI、 after3months post-PCI) levels are significant differences (P<0.05).2、 The serum APN of treatment group before PCI is5.68±2.14μg/mL, declined to4.69±1.90μg/mL after1day post-PCI, added to7.08±2.20μg/mL after1month post-PCI, lasty increased to9.43±2.31μg/mL after3months post-PCI, pairwise comparisons in the treatment group are significant differences (P<0.05); The serum APN of the control group before PCI is5.01±1.89μg/mL, decreased to3.86±2.16μg/mL after1day post-PCI, increased to6.02±1.98μg/mL after1month post-PCI, eventually added to8.14±2.17μg/mL after3months post-PCI, pairwise comparisons in the control group are significant differences (P<0.05). Between the two groups, the preoperative serum APN is no significant difference, but whose (after1day post-PCI. after1month post-PCI、 after3months post-PCI) levels are significant differences(P<0.05).3、 The percentage of clinical efficacy in the treatment group is better than the control group, but have no significant difference. Conclusions:1、 The capusle of Rhodiola maybe be reduced the serum TNF-α level in patients after PCI, which, inhibited the inflammatory response, were achieved the protection of myocardial.2、 The capusle of Rhodiola can be increased the serum APN level in patients after PCI, which, through increasing the level of adipokines, were proced the protection of myocardial.3. The capusle of Rhodiola maybe improve the patient’s clinical symptoms.