| Objective:With high-performance liquid chromatography (HPLC) method for determination of the content of aristolochic acid A in Guang fang ji and the feasibility of detoxification, plasma and kidney tissue of rat, to study the kidney toxicity of Guang fang ji and the feasibility of detoxification by compatibility.Methods:According gangji-group to the main square, compatibility fangji with white ginseng, cinnamon, Poria cocos,Coptis and psyllium, divided into10groups:blank control group, single flavor fangji group fangji white ginseng group fangji The Poria group, fangji cinnamon group, fangji Coptis group fangji front group fangji has been born white ginseng Poria cinnamon group, fangji has been born drying parameters Poria cinnamon Coptis group and fangji has been born drying parameters Poria cinnamon car before the group. use high performance liquid chromatography to measure the content of AA in the herbs, kidney and tissue in plasma.Results:The wide in can cause kidney damage has been under dose, And compatibility of rhizoma coptidis in rats after crude, plasma and kidney tissues in the measured AA content at least, Second is CheQianZi, tuckahoe, cinnamon, born and sun; content of compound compatibility of the title aristolochic acid is less. SD rats in large doses medicine7daysConclusion:By the appropriate compatibility, the toxicity of fangji can be reduced, while fangji compatibility Coptis group measured the content of AA is the lowest, which may contain a large number of alkaloids related with berberine; SD rats large doses of short-term to the drug experiments, short-term compatibility fangji security than single fangji. |
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