The Expression And Clinical Significance Of Rhoa And Nm23-H1in Different Cervical Tissues

Objective: To study the expression of RhoA and nm23-H1in thenormal cervical epithelium(NCE), cervical intraepithelial neoplasia(CIN)and squamous carcinomas of cervix(SCC), and to analyze therelationship of RhoA,nm23-H1with squamous carcinomas of cervixdevelopment and progression. Methods: Immunohistochemistry SP wasused to measure the expression of RhoA and nm23-H1in66cases ofSCC,28cases of CIN and10cases of NCE. Results:1.The expressionof RhoA that could hardly be detected in NEC, RhoA positive-expressionrate in CIN and SCC were39.29%and72.73%separately, theirexpressions have significant differences(P<0.05). nm23-H1positive-expression rate in SCC was54.55%， which was lower than it in CIN（90%） and NCE tissues （71.43%， P<0.05), and there was nosignificant difference in nm23-H1between NCE and CINgroups(P>0.05). RhoA positive-expression associated significantly withtumor cell diferentiation and lymph node metastasis (P<0.05)．nm23-H1positive-expression associated significantly with lymph node metastasis(P<0.05)． There was no relationship between RhoA and nm23-H1positive-expression in SCC （rs＝–0.235，P>0.05）.Conclusion: Theincreased expression or loss of RhoA and nm23-H1may play animportant role in the development and progression of the cerviealcarcinoma，which is associated with poor prognosis．...