Association Of Serum γ-glutamyltransferase Level And Insulin Resistance In Patients With Type2Diabetes Mellitus

Objectiveobservation of type2diabetes mellitus (T2DM) who are using insulin treatment early and below normal index:BMI、SBP、DBP、FPG、Hollow c-peptide、UA、 ALT、AST、GGT、TG、TCH.,et al, comparing the differences of the clinical observation data of more patients with normal group, Using relevant statistical methods, Analysis the relationship of each index and clinical observation of insulin resistance index, Discussing about the most important affecting factors GGT、type2diabetes and the correlation of insulin resistance.MethodsSelect104cases of type2diabetes patients (set to T2DM group) in January2010to December2010in jinan city of shandong university hospital affiliated hospital center endocrine department (According to1999WHO experts committee diagnosis standard, and with reference to the2010ADA diabetes diagnosis new guidelines), Male59, female45.The same conditions of74normal subjects(set to NC group), Male44, female30.Detecting heigh、weight、blood pressure、γ-glutamyltransferase、 FPG、Hollow c-peptide、UA、ALT、AST、TG、TCH, et al, compared the difference of the measured index between the two groups, And analyze relevancy of the IR and other factors.Through multiple stepwise regression analysis, Observing the related of index and insulin resistance closely.Results1.Comparing of general material with biochemical index comparison:59patients men of type2diabetes group, accounting for56.73%of the case group.Normal control group men44cases,accounting for59.46%of the control group.The T test P= 0.718,far greater than0.05,The two groups of sex ratio that there is no difference.Type2diabetes group mean age is58.2±15.57years.Normal control group mean age is54.77±11.15years,show age no difference.So patients and normal group of the age, sex ratio are similar,Ensure the comparability of two groups.From the two groups of data analysis shows, BMI、SBP、DBP、FPG, Hollow c-peptide、GGT numerical obviously higher than those in the control group. P<0.05, it has significant statistically meaning. UA、ALT、AST、TCF、TG numerical is no difference between the control group. P>0.05,it is no statistical difference.2. Correlation between T2DM group and factors of insulin resistance index:the Pearson correlation analysis,age、sex、history、ALT、AST、TCH and insulin resistance index not related. BMI、SBP、DBP、FPG、Hollow c-peptide、UA、GGT、 TG and insulin resistance index were positively correlated (r=0.382、r=0.352、 r=0.284、r=0.313、r=0.836、r=0.244、r=0.369、r=0.217, in addition to uric acid, triglyceride,P<0.01),it is significant statistical significance.3. multiple stepwise regression analysis of various factors and insulin resistance index:To all people with diabetes,multiple stepwise regression analysis,with insulin resistance index as the dependent variable.Enter the return equation for BMI、SBP、 GGT.The results shows that a linear relationship observed in the three indexes and insulin resistance index.Conclusion1.From multiple stepwise regression analysis showed:Blood pressure、body mass index and GGT play an important role in the process of insulin resistance.In addition to body mass index, GGT plays an most important role in insulin resistance.2.In the exclusion of liver disease and other affecting factors, GGT can be used as an independent predictor of insulin resistance, GGT might become type2diabetes risk factors of forecasting index.