The Clinical Features And Treatment Prognosis Analysis Of79Cases Of Patients With Drug-Induced Liver Injury

Background:Drug induced liver disease (DILI) is a liver disease caused by damage or allergic reactions due to toxicity of drugs and metabolites. With the increasing types of clinical drugs, the broad application of combination therapy and the promotion of Chinese herbal medicine, the incidence of drug induced liver injury increased year by year, the serious harm caused by DILI gradually attracted people’s attention.Objective:To further explore the predisposing factors, clinical features,diagnosis and treatment of the drug induced liver disease.To deepen the understanding of the disease and to improve the diagnosis,prevent the occurrence of this disease.Methods:The retrospective analysis was performed on the clinical data of79patients diagnosed drug-induced liver injury in Gastroenterology and Hepatology department of our hospital from March2009to March2012.The observing contents include:the patient’s gender, age, history of allergies, medication history, medical history, clinical manifestations, laboratory tests, treatment and outcome.To comprehensive analyse the predisposing factors and the characteristics of drug induced liver disease.Results:The drugs that cause drug induced liver disease primarily contain Chinese herbal medicine, anti-TB drugs, antibiotics and antipyretic-analgesic drugs. The basic diseases lead to drug induced liver disease comprise tuberculosis, hepatitis B, diabetes, hyperthyroidism, alcoholism, cancer,etc. The main clinical manifestations were anorexia, fatigue, nausea, vomiting, fever, skin and sclera yellow dye, significantly abnormal liver function,etc. There were better prognosis after withdrawal and hepatoprotective treatment.Conclusion:We should attach great importance to drug induced liver disease and strengthen drug supervision.In addition,we also should master the ingredients, contraindications, adverse reactions and interactions. The predisposing factors of drug-induced liver are age, occupation, types of drugs, medication time, medication method, and a merger of the underlying disease.