The Observation And Measurement In Human Hippocampal Morphology And MRI

ObjectiveThe hippocampal formation is an important part of human brain, itresponsible for the function of human memory storage, informationprocessing, organs of the human body, emotion and some physiologicfunctions. Hippocampal morphological changes associated withAlzheimer’s disease, Temporal lobe epilepsy, Schizophrenia, Depression orother diseases. The study on hippocampal formation of the morphologicalhelp to explain a variety of neuropsychiatric disorders and theirpathological processes, it help to guide the clinical diagnosis and treatmentof diseases associated with hippocampal morphological changes. Alongwith the development of sectional anatomy and medical imagingtechnology in recent years, many scholars on the hippocampal formation ofthe morphologic changes associated with the disease were discussed. But isrestricted to the hippocampus structure of its anatomical structure of the complexity and the diversity of research methods and other shortcomings,the results tend to be quite different, it is unable to form a unified andconvincing standard. Therefore, it is urgent to regulate the anatomicalstructure of hippocampal structure, in order to guide the currentmorphological study. Based on this, through the acquisition of normal adulthippocampal formation in vivo and magnetic resonance images, we willresearch in its normal anatomical structure, and the measurement ofhippocampal formation volume, area, linear index and a number of data,with a view in order to provide some valuable information for standards ofdata in normal adult hippocampal morphology.Methods1.Selected31cases (male17cases, female14cases) of the normal level ofHan Chinese adult cadaveric brain images. Using the image in suprasellarcistern to measure the hippocampal area, the terminal brain area, themaximum transverse diameter of hippocampus, maximum radius, temporallobe interuncal distance, lateral recess width, telencephalon, and so on.2.Selected51patients (male21, female30) of random sample withoutsignificant neuropsychiatric disorders in healthy Han adults, using GE3.0TNMR spectrometer on the line perpendicular to the long axis of thehippocampus of oblique coronal MR scan; acquisition sequence for3DBRAVO sequence, sequence parameters: TR8.4, TE3.2, TI450, FOV:24.0matrix:224×224，NEX1, thickness1mm; no interval between successive scanning, head coil for receiving coil, scanning layers of137~245layers, an average of158layer, scanning range covering the wholebrain; the obtained image on a workstation for cross-sectional and sagittalreconstruction, and adjusted to the best contrast; scanning after the datainto the ADW4.2image processing workstation, in coronal, sagittal, levelthree range while under observation, measurement of hippocampal volume,height, width, hippocampus hippocampus hippocampus axis length data.3.All the data standardization processing uses the SPSS13.0statisticssoftware for analysis of the data is poor, the side difference distribution, aswell as the linear index and hippocampal volume correlated degree.ResultsThe observation of HPF morphologyThe right hippocampus radius after Standardization in female is largerthan male, other data value are present in males than in females. whichhemisphere of the brain area (P<0.05), hippocampal transverse diameter(P<0.01), cranial area had significant difference (P<0.01). Except the malebrain hemisphere area value, lateral recess width was left the value greaterthan the value of more than, the data showed a right greater than left, therewere no significant differences; standardization after hippocampal area,hippocampus radius were women than men, hippocampal transversediameter (P<0.05), lateral recess width, interuncal distance in males than infemales, in addition to the lateral recess width, other data are right greater than left, in which hippocampal transverse diameter of gender differenceshave significant differences, the data showed no significant differences formore than.Pearson correlation analysis shows, in addition to standard anteriorlateral recess width, hippocampal radius, transverse diameter, interuncaldistance were associated with hippocampal area were significantly related,particularly in the hippocampus radius most closely; after standardization,visible only in hippocampus and hippocampal area closely related the radiusvector, the data were not significantly related to more than.The observation of HPF morphologyEach set of data statistics to see the chart, which square differencehomogeneity test confirmed the homogeneity of variance, with the singlefactor variance analysis showed that: the hippocampal volume afterstandardization (head), normalized hippocampal volume (body), normalizedhippocampal volume (tail), the hippocampal volume in length afterstandardization (head), the length of the hippocampus after standardization(body), normalized hippocampal length (tail), the hippocampus axis lengthwidth after standardization, the width of the temporal horn afterstandardization had significant differences in gender (male>female, P<0.05).Interuncal distance, width of the temporal horn had significant difference insex (male>female, P<0.01); standard length (head), normalizedhippocampal length (tail) had significant difference in side(right>left, P<0.01). Standard hippocampal length (body), normalized hippocampalaxislength had significant difference in side(left>right, P<0.01).Pearson correlation analysis present the linear indicators most closelycorrelated hippocampal volume after standardization degree are standardhippocampal width, hippocampal longitudinal width of the temporal hornafter standardization, hippocampal volume after standardization(tail).Conclusion(1)Hippocampal structure is complex and irregular, differentsegmentation methods may lead to data differ in thousands of ways, so toidentificate and delimitate on hippocampal structure has some significatemeaning.(2)The data in presence of difference in sex and sides, before and afterthe treatment in standardization the distributions is different. So shouldconsider it on the data in practical work.(3)The hippocampus radius, width of hippocampus or other linearmeasurement data can be used as a study of the initial screening index inhippocampal morphological changes.