| Objective The aims of this study were to clarify those factors that recurrence after curative resection and to investigate the clinicopathological features and prognostic factors in Ampullary adenocarcinoma.Methods The medical records of patients that underwent curative surgery for ampullary carcinoma from January1989to Dec2010at Cancer Hospital of Chinese Academy of Medical Sciences were retrospectively reviewed. One hundred and thirty two patients that underwent curative resection for ampullary carcinoma were enrolled in this study. One pathologist reviewed all pathologic reports and histopathologic findings. Data on clinicopathologic factors and disease free and overall survival were analyzed by Statistical Package for the Social Sciences (Release17.0, SPSS, Inc).Results The5-year disease free survival rates and overall survival rates of the132study subjects were49.5%and55.3%, respectively. Univariate analysis revealed that an advanced T stage (p=0.000), nodal metastasis (p=0.000), poor differentiation (p=0.022), tumor size (p=0.009), lymph node ratio (p=0.001) as significant prognostic factors. Pancreaticoduodenectomy (PD) and local resection for early tumors (T1) had no significant survival differences (p>0.05). Multivariate analysis showed that the advanced T stage, the presence of lymph node metastasis significantly increased the risk of recurrence.Conclusion Radical surgery is still the main treatment for ampullary carcinoma. Ampullary cancer lymph node metastasis was more common in the pancreatic lymph nodes around. The primary tumor advanced T stage, lymph node metastasis were independent prognostic factors of influence survival. |
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