Relationship Between Levels Of FDP D-dimer And Disease Activity In Patients With Rheumatoid Arthritis

Objective： We observed plasma levels of fibrinogen degradation products (FDP)，D-dimer(DD) and Fibrinogen (Fg) in patients with Rheumatoid Arthritis and explore therelationship between enhancement of the coagulation system and disease activity．Methods： Patients were divided into the active group and the remission group andfifty patients were included in each group．Hematological variables，including FDP，DD，Fg，and disease activity parameters including erythrocyte sedimentation rate (ESR)，C-reactive protein(CRP) levels and rheumatoid factor (RF) titer weremeasured．Two-sample t-test and Chi-Square test were used for statistical analysis bySPSS11.0software package．Quantitative data was expressed as mean±standarddeviation and analyzed with Two-group t-test．Linear correlation test was used to assessthe associated factors for disease activity．Results： Age and sex were comparable in the two groups（P>0.05）．The FDP，DD and Fg were significantly higher in patients with active disease[﹙12.0±8.2﹚μg/ml,(3.1±3.1) μg/ml,(4.6±1.4）g/L]than those in patients with remission[﹙2.1±1.1﹚μg/ml,(0.5±0.4) μg/ml,(3.0±0.6）g/L](p <0.01)．There was nodifferences in gender distribution in FDP and DD（P>0.05）．However，Fg was significantlyhigher in men than that in women（P<0.05）．FDP showed a significant positive correlationwith DAS28(r=0.48，P<0.01）and ESR（r=0.28，P<0.05）．DD correlated positively andsignificantly with ESR and DAS28（r=0.69，0.52，P<0.01）．Fg was significantly positivelycorrelated with DAS28，CRP and ESR (r=0.57，0.64，0.68，P<0.01）．FDP，DD and Fgdid not show correlation with RF (r=-0.07、0.06、-0.01，P>0.05）．Conclusion: FDP and DD correlate well with disease activity and were importantdisease activity parameters for RA．The rank of accuracy of FDP，CRP，DD，ESR，Fg and RF for disease activity assessment of RA patients in a declined manner．...