A Clinic Study Of80Cases On Treatment Of Chd With Guanxinping

Objective:The aim of this study is to observe the changes of symptoms, ECG changes using Guanxinping, compared with "xinkeshu" as positive control in the treatment of Coronary heart disease （CHD）.Also the clinical effect and safety of such patients by using Guanxinping is to be evaluated. Blood fat, NOS, oxidative stress index SOD、GSH, inflammatory reaction is the most important index to be observed.Method:1.All of the observations come from Jiangsu TCM hospital Cardiovascular in-patient Department. The total number of the observations is160. Among them80observations in treating group were treated with guanxinpin, while the rest as control group were treated with xinkeshu in one month. Symptoms, ECG, blood fat and endothelium function index was observed. Safety and clinic efficacy was also evaluated by using both therapeutic and control group for one month.. NO use NR（nitrate reductase） method to analysis, SOD use XO （xanthine oxidase） method to analysis, NOS、GSH use coloeimetry to analysis. ET-1、TXB2、6-keto-PGF1α、use radioimmunodiffusion to analysis. Hs-CRP use immunoturbidimetry（ITM） to analysis.2. Statistical analysis:Descriptive statistic analysis Qualitative index use percentage and Quantitative index use mean and standard deviation. In evaluating significance, the Chi-square analysis was used in Quantitative data and "t" analysis was used in evaluating qualitative data. Statistical analysis was done with SPSS software.Result:1. In clinic efficacy:Both therapeutic and control group can decrease angina pectoris frequency and duration P<0.05, of which the therapeutic group is more evident P<0.05.2. In ECG efficacy:Both therapeutic and control group can improve ECG efficacy, but there is no difference between them. P>0.05.3. In TCM symptom efficacy:Both therapeutic and control group can improve each TCM symptoms, of which the therapeutic group is more evident P<0.05. Both therapeutic and control group can improve grading of illness, of which the therapeutic group is more evident P<0.05.4. In blood fat analysis:The control group can lower LDL P<0.05)\, the therapeutic group can also lower LDL but has no statistical significance P>0.05. Both of the two groups can elevate HDL, but each has no statistical significance （P>0.05）.5. In endothelium functions:NO treatment group compared with before treatment increased （P<0.05）, control group treatment （P>0.05）; elevated in the NOS two groups compared with before treatment. P<0.05;₆-keto-PGF1α in the treatment group were higher than before treatment P for trend>0.05, control group treatment decreased （P<0.05）:ET treatment group was lower than before treatment （P<0.05）. the control group （P<0.05） higher than before treatment; TXB2treatment group was lower than before treatment （P<0.05）. the control group, P>0.05higher than before treatment; Indicators of the treatment group improved significantly compared with the control group, the difference between the groups （P <0.05）.6. In oxidative stress and inflammatory reaction:The therapeutic group can elevate SOD and GSH （P<0.05）. And can also lower hs-CRP （P<0.05）. The control group can elevate SOD. But there is difference between the two groups.（P<0.05）.Conclusion:Guanxingping which presents the method of supplementing qi and nourishing yin, promoting blood flow and eliminate phlegm to treat coronary heart disease has positive curative effect and can be used in clinic treatment, the therapeutic mechanism is to protect VEC and to improve EDF,blood fat dysfunction, antioxidation and antiinflammatory...