Effects Of Xuezhikang On Insulin Secretion And Insulin Sensitivity In Experimental Study

Objective:Experimental study to explore of Xuezhikang for glucose and lipid metabolism, for insulin secretion and insulin sensitivity, and to study its possible mechanism. In order to play better Chinese medicine to improve the role of glycolipids in clinicalMethods:40male12weeks of age, clean level in db/db mice (congenital diabetic mice model),20weeks of age, littermates db/m mice(non-diabetic control group),the db/db mice were divided into two groups, were given six weeks the Xuezhikang0.3g/kg.d and placebo (5%gum arabic) suspension orally once a day; db/m, mouse non-diabetic control group, an equal volume of saline once a day gavage. Measurement of their weight after six weeks, fasting serum cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), fasting blood glucose (FBG), fasting insulin (FSI) and other physiological and metabolic indicators. And research the influce of Xuezhikang to right insulin secretion and insulin sensitivity in db/db mice IPGTT, islet first phase secretion, pancreatic β cell content within the islet oxidative stress. Use SPSS for Windows11.0statistical software on the above data, statistics, analysis of Xuezhikang for glucose and lipid metabolism, insulin secretion and insulin sensitivity, and to explore its possible mechanism.Results:After6weeks of treatment, Xuezhikang in TC and LDL-C, TG and of FBG and FSI significantly lower than the db/db control group (P<0.05);120minutes after glucose loading, Xuezhikang group of glucose decreased (P<0.05); under the glucose curve area and insulin area under the curve were lower than in db/db placebo control group (P<0.05). Xuezhikang group of islets first phase secretion to be improved.6weeks after dosing, Xuezhikang can significantly reduce the loss of islet beta cells.;reducing islet cell oxidative stress.Conclusion:Xuezhikang can effectively improve glucose and lipid metabolism disorders, improve insulin secretion and insulin sensitivity. And improve insulin secretion in reducing the loss of islet beta cells, reduce the role of pancreatic islet cells and oxidative stress response targets.