The Expression Of Ki-67and Bcl-2and Their Significance In The Endometrial Polyps In Postmenopausal Women

Objective:Endometrial polyps are one of the common gynecological diseases. EP often occur in women over the age of35. With increasing age, the incidence is also increased. The morbidity and malignant transformation rate is significantly increased in postmenopausal women. It has seriously affected the physical and mental health of women. It is widely recognized that it is different in the pathogenesis between the premenopausal and postmenopausal endometrial polyps. The previous study of postmenopausal endometrial polyps usually selected the research sample including the postmenopausal endometrial polyps and the surrounding normal postmenopausal endometrium compared, ignoring that there might be different between them. The present study was designed to detect the presence of proteins related to proliferation (Ki-67) and apoptosis (Bcl-2) by immunohistochemistry (SP method) in the gland epithelial and stromal cells among the endometrial polyps, the surrounding normal endometrium compared and the normal endometrium in postmenopausal women, and to compare them with changes observed in three groups. We would discuss the role of proliferation and apoptosis in postmenopausal endometrial polyps. Therefore, it would provide a theoretical basis for the better clinical treatment.Methods:Choose50cases of postmenopausal endometrial polyps patients, and take their polyps organization for polyps group, corresponding surrounding normal endometrium organization for endometrial group, and30cases of normal postmenopausal endometrium for control group. Immunohistochemical streptomycin resistance to biological grain protein-peroxidase connection method (SP method) is used to detect the expression of Ki-67and Bcl-2in the gland epithelial and stromal cells of three groups. Then, the results were analyzed.Results:1. In this study, Ki-67expression in the glandular epithelium and stroma between the polyps group and endometrial group are significantly different (P<0.01); Ki-67expression in the glandular epithelium and stroma between the polyps group and control group always make significant differences (P<0.01); there are differences in its expression in the glandular epithelium of the endometrium group and control group (P<0.05), while no significant expression in the stroma (P>0.05).2. Bcl-2expression in the glandular epithelium and stroma between the polyps group and endometrial group are significantly different (P<0.01); Bcl-2expression in the glandular epithelium and stroma between the polyps group and control group always make significant differences (P<0.01); there are no significant expression in the glandular epithelium and stroma between the endometrial group and control group (P>0.05).Conclusion: Postmenopausal endometrial polyps occur with the common high level of Ki-67and Bcl-2expression in local polyps. This makes the excessive proliferation of local endometrial tissue cells and escapes the normal apoptosis, eventually leading to the formation of polyps. Polyps could not be formed in endometrial group when the express of Ki-67is only high in the glandular epithelium, as the express of Bcl-2is normal, in the gland epithelial and stromal cells. Bcl-2plays a dominant role that is likely to prevent apoptosis to prolong cell survival. this appears to be responsible for the growth of postmenopausal endometrial polyps.