Sequential Therapy In The Treatment Of Ulcerative Colitis(UC) In Active Phase Clinical Observation

Objecti ve:Ulcerative colitis is an unknown etiology, difficult to cure, easy to difficult disease recurrence and carcinogenesis. In recent years the disease has a rising trend. Mainly as abdominal pain, diarrhea, mucus, pus and blood, tenesmus. The lesions may involve the rectum and sigmoid colon can also be invaded and to other parts or all of the colon. Diagnosis mainly relies on colonoscopy and intestinal mucosa biopsies. Observe Chinese medicine sequential therapy, the subject light to moderate ulcerative colitis active phase (TCM is colorectal damp-heat syndrome), clinical observat ion and6months follow-up. Objective evaluate the efficacy and safety for the treatment provide the basis for clinical application.Methods:Clinical trials use randomized, parallel-group method,50cases diagnosed by colonoscopy with mild to moderate active ulcerative colitis and patients with TCM is colorectal damp-heat syndrome is divided into treatment group (25cases) and control group (25cases) of SASP. The two groups in gender, age, disease duration, disease distribution, extent of disease before treatment, colonoscopy, and symptom score, no significant difference between comparable (P>0.05). The treatment group received sequential therapy, that is UC â…¡ fang, daily, fried twice, mixed300ml, taken twice, and the dregs and fry twice, mixing concentrated to150ml, Take the proprietary Chinese medicines Jiechangning5g dissolved, Every night before bed to retain the enema; Control group was given the oral SASP4-6g, divided into four oral treatment. The treatment lasted12weeks,24weeks after the end of treatment follow-up, Observed the change of symptoms before and after treatment, After statistical processing, compare symptom scores before and after treatment, the symptoms, poor response rate, relapse rate etc. Evaluate the efficacy and safety of the drug.Results:1.Compare two groups of TCM Syndrome, treatment group of TCM Syndrome better than the control group (P<0.05), and compare two groups of clinical cure rate,P<0.05, the difference was statistically significant.2. Patients with symptom scores between the two groups were compared before and after treatment. Statistically, there were significant differences (P<0.05); Symptom score before and after differences in treatment group better than in the control group(P<0.05), That is treatment group better than the control group on the improvement of overall symptoms in patients.3. Improve abdominal pain, diarrhea symptoms in the treatment group and control group efficacy; Improve blood and pus symptoms better than the control group.4. No adverse reactions during treatment, the treatment group and control group had three cases of adverse reactions, two groups of poor response rates there are significant differences, control group than the treatment group. Illustrates the safety of the treatment group was higher.5.3months after treatment, patients with complete remission and effective were followed up for6months, two groups were compared the recurrence rate after statistical processing, the treatment group lower than the control group.Conelusions:TCM sequential therapy in the treatment of mild to moderately active UC (colorectal damp-heat syndrome) in TCM syndrome efficacy, symptom score reduction, improvement of the main symptoms, especially the pus and blood will be improved to better than sulfasalazine, and low recurrence rate, no significant side effects. Therefore, TCM sequential therapy is effective and safe treatment options for hot and humid with mild to moderate active UC, it is worth the promotion of clinical applicat ion.