Clinical Study Of Resolving Phlegm And Removing Blood Stasis In Treatment Of Chronic Gout

The main symptoms of chronic gout are frequent seizures, multiple joint involvement, continuing arthritis, bone erosion and loss of joint functions. It often associated with metabolic symdrome, hyperlipidemia, diabetes, hypertension and cardiovascular disease. It leads to heavy burdens to families and society. In recent years, the prevalence of gout was gradually increased. It happens more and more among young adults. Uric acid lowering drugs fall into two categories, one category is to promote uric acid excretion, the other is to suppress the production of uric acid drug, but these drugs have toxic side effects in long-term application.Based on the clinical experiences of our department, according to the law of the disease, aiming at the features of chronic gout by obstruction of phlegm and blood stasis, we prescribed a compound recipe with the therapeutic principle of resolving phlegm and removing blood stasis. In the early clinical observation, the prescription had got an obvious therapeutic effect. As the observation periods of clinical research at the present mostly were short, lacking long-term observation, in order to evaluate the mid-term and long-term clinical therapeutic effect, safety, we performed this research.We enrolled in this study30patients with chronic gout and with the syndrome of obstruction of phlegm and blood stasis. Efficacy of the syndrome, laboratory measures and the evaluation of safety after three-month treatment was assessed. The results were compared with allopurinol group by parallel study. The results are:Improvement of blood uric acid:after1months treatment, the herbs group showed no statistically significant difference, but after the treatment of2—3months showed statistically significant differences (P<0.01).There were no significant difference between herbs group and allopurinol group in mid-term effect.Indexes of assessing therapeutic effect:herbs group was effective in reducing the counts of tender joints and swollen joints, and lowering the grades of pain assessment by VAS. Herbs group could take effects early. Systemic symptom score:herbs group showed statistical differences.Safety:The incidence of adverse reactions of traditional Chinese medicine group was low.Conclusion:Reducing phlegm and removing blood stasis can relieve the patients with joint pain, swelling symptoms, lowering serum uric acid steadily. Taking herbal medicine has fewer adverse reactions.