| BackgroundAlong with the development of science and technology, noninvasivetreatments have become a topic which people pay more and more attentionto. HIFU is new technology of non-invasive tumor treatment developedthis year.The principle is that through the focus of ultrasonic, put the focuspoint in the target of tumor treatment, made the target temperatureinstantaneous to60℃or more, cause the tumor organization becomecoagulation necrosis, and treat tumors. In order to realize the the accuratepositioning before the HIFU treatment and perioperative before the real timemonitoring and evaluation curative effect, safe and effective monitoringmethod is very important. At present clinically, ultrasound monitoring is themost extensive application because of its no radiation, good real-timeperformance. Ultrasound monitoring use the traditional gray or grey value tojudg the coagulative necrosis of organization, later research found that，through the monitoring method，there were part of the discriminant error inthe condition of coagulative necrosis tissue before and after irradiation target areas, so it is necessary to look for a more precise way ofdiscrimination.The present study through the related function analysis of theultrasonographic before and after irradiation in different conditions to lookfor a more accurate monitoring method of HIFU treatment to provide strongguarantee.Methods(1)120rabbits with VX2portability breast cancer at the second leftbreast were randomly divided into4groups(90W,100W,120W,150Wgroup), used HIFU fixed-point irradiation, radiation time were3S,observed the change of the ultrasonographic gray and grey value at targetareas before and after irradiation, and took it for related function operation,with SVM screening as the parameter values of judgment standard, withthe pathologic result as standard, compared the judgment sensitivity of twodiscriminant way in groups or whole.(2)60rabbits with VX2portability tumor at the second bilateralbreast were randomly divided into90W,120W,150W group, each grouphad20rabbits, used HIFU fixed-point irradiation, radiation time wereunified for3S, injected microbubble when irradiated the left tumor, tookthe right group as a control, observed the change of the ultrasonographicgray and grey value at target areas before and after irradiation, and took theultrasonographic for related function operation, used the pathologic resultas the standard,compared the accuracy and stability of gray discriminant way and related function discriminant method in control group and Microbubble group.Results(1) In90W group, the number of sample coagulative necrosis (CN)was8, the number of sample did not occur coagulative necrosis (NCN)sample was22, the convicted rate of relevant function was83.33%, theconvicted rate of gray was53.33%, the difference was statisticallysignificant (P <0.05); In100W group, the number of CN sample was11,NCN sample was19, the convicted rate of relevant function was83.33%, theconvicted rate of gray was60.00%, the difference was statisticallysignificant(P <0.05); In120W group, the number of CN sample was16,NCN sample was14, the convicted rate of relevant function was86.67%, theconvicted rate of gray was66.67%, the difference was statisticallysignificant (P <0.05); In150W group, the number of CN sample was24,NCN sample was6, the convicted rate of relevant function was93.33%, theconvicted rate of gray was80.00%, the difference was statisticallysignificant (P <0.05). Used gray judgment, the difference between90Wgroup and150W group was statistically significant (P=0.028);The relatedfunction analysis of ultrasonographic of120samples before and afterirradiation showed that the general convicted rate was86.70%，which washigher than the the convicted rate of gray(65.00%),the difference haveobvious statistical significance (P <0.05). (2) Calculated the related function values of ultrasonographic ofnecrosis tissue samples in each dosage group before and after irradiation, thesmaller relevant function values were, the deeper the level of target tissuewas,the greater the area was. In90W group, the relevant function value ofmicro-bubble group was0.56±0.02, the control group was0.65±0.07, thedifference was statistically significant(t=-2.66, P=0.0159); In120Wgroup, the relevant function value of micro-bubble group was0.50±0.08, thecontrol group was0.61±0.09, the difference was statistically significant(t=-3.60, P=0.0011); In150W group, the relevant function value ofmicro-bubble group was0.48±0.08, the control group was0.54±0.06, thedifference was statistically significant(t=-2.23, P=0.0329).In themicro-bubble group (60samples), the number of the CN sample was44, theconvicted rate used relevant function analysis was86.4%, the convicted rateof gray was75.0%, the difference was statistically significant (P <0.05); Inthe micro-bubble group,the munber of NCN sample was16, the convictedrate used relevant function analysis was81.3%, the convicted rate was62.5%, the difference was statistically significant (P <0.05);In the controlgroup(60samples), CN sample was35, the convicted rate used relevantfunction analysis was85.7%, the convicted rate was71.4%, the differencewas statistically significant (P <0.05);In the control group, NCN samplewas25, the convicted rate used relevant function analysis was76.0%, theconvicted rate was56.0%, the difference was statistically significant (P < 0.05);Used gray evaluation,the difference between micro-bubble group andcontrol group was statistically significant (P <0.05); Used related functiondiscrimination, the difference was not statistically significant (P>0.05).Took the ultrasonographic of120samples before and after irradiation forrelated function analysis, the general convicted rate was83.3%, which washigher than the convicted rate of gray (68.3%), the difference had obviousstatistical significance (P <0.05).ConclusionAnalysed the target area ultrasonographic of rabbit breast tumor afterHIFU irradiation, the accuracy and sensitivity of relevant function is betterthan gray evaluation. In nano micro bubble conditions, gray discriminationis significantly higher accuracy than without bubble, relevant functiondiscrimination is still higher than the accuracy of gray evaluation, comparedwith the without bubble conditions, relevant function discrimination had nostatistical difference, its stability is obviously superior to gray evaluation.Use the relevant function discriminant way, can improve the quality ofmonitoring HIFU, it is expected to become the new monitor mode. |
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