The Clinical Significance And Correlation Analysis Of HIF And VEGF Expression In Cervical Squamous Cell Carcinoma

Objective: To investigate the expression of HIF-2α and VEGF in normalcervical tissue and cervical carcinoma, analyzing differences and correlation betweenthem, and to explore their clinical significance.Methods:1. Specimens surgically resected from64cases of cervical carcinoma and22cases of cervical benign disease were collected. The expression of HIF-2α and VEGFin them was detected by immunohistochemistry.2. Real Time PCR was used to detect the expression of HIF-2α and VEGF innormal cervical tissue and cervical carcinoma.Results:1. The result from Real Time PCR showed that the expression of HIF-2α mRNAand VEGF mRNA in cervical carcinoma was significantly higher than that in normalcervical tissues (P<0.01). There are significant differences between normal cervicaltissue and cervical carcinoma.2. The result of immunohistochemistry showed that there are little expression ofHIF-2α and VEGF in normal cervical tissues, and cervical carcinoma tissues had asignificantly increase compared with that in normal cervical tissues(P<0.01). Andthere was a significant positive correlation between the two factors.Conclusion:1. The high expression of HIF-2α and VEGF in cervical carcinoma may playan important role during the initiation and development of cervical carcinoma.2. There was a significant positive correlation between HIF-2α and VEGFfactors.The high expression of HIF-2α and VEGF in cervical tissues may beinvolved in the progress of cervical carcinoma.