Consistent Decoction In Treating Chronic Cough(Yin Deifciency Of Liver And Kidney Syndrome) In The Mechanism And Clinical Research

Purpose: Observation of Decoction on chronic cough (liver and kidney yin deficiencytype) clinical efficacy, to prove that the traditional Chinese medicine on the treatment ofchronic cough effect.Methods: This study is through the observation of the Affiliated Hospital of ChangchunUniversity of Traditional Chinese Medicine from2011January to2012Department ofrespiration in January outpatients and therapy in patients with60cases, diagnosed by clinicaldiagnostic criteria for chronic cough. Using random digit grouping control treatment, thetreatment group, control group30cases. The treatment group to modified YiguanjianDecoction, one agent is taken2times, early, late clothing; the control group Suhuang Zhikecapsule,3times daily,4capsules each time. The two groups were observed respectively for7daysResults: Patients taking consistently decoction after the symptoms improvedsignificantly, improve the rate is higher, than the control group (Suhuang Zhike capsule) hada significant difference (P <0.01), patients usually taking2-3days after symptoms improved,a week or so symptoms relieved, the total efficiency of90%. The control group SuhuangZhike capsule after oral administration, the drug slow onset, generally10days in patientswith symptomatic remission, with an efficiency of86.7%. Considering the possible linesDecoction absorption is powder quickly, more easily absorbed.Conclusion: XianKe Granule could inhibit weight declining, compared with the modelgroup were significantly difference (p<0.05or p<0.01). XianKe Granule middle-dose cansignificantly reduce the different periods of pulmonary fibrosis in rat TNF-α content,compared with the prednisone group were the obvious difference (p<0.05), and that showsXianKe Granule to pulmonary fibrosis have more obviously preventive and therapeuticeffects, its mechanism may be related to inhibiting the expression of TNF-α.