The Clinical Research On Hashimoto’s Thyoiditis By The Erxianxiaoying Prescription

Purpose:By contrasting with western medicine alone program, it aims to evaluate treatmen efficacy and safety of traditional Chinese medicine ErXianXiaoYing prescription on treating hashimoto’s thyroiditis and hypothyroidism. It also explores the role of tumor necrosi(?) factor-alpha (TNF-alpha) in Hashimoto’s thyroiditis and the effects of drugs on indicators, whic(?) serves to provide a theoretical basis for clinical Chinese medicine treatment of Hashimoto’(?) thyroiditis.Methods:According to randomized and controlled clinical observation principle, the autho randomly divided60patients into two groups, who are consistent with Hashimoto’s thyroiditi(?) and hypothyroidism, as well as the TCM Prosperity of differentiation with spleen and kidney Yang, phlegm and blood stasis syndrome diagnosis standard of mutual in line with the patients Based on conventional western medicine therapy, the30patients’medicine of treatment group i(?) plus with traditional Chinese medicine, one dose daily, successive for12weeks. Before and afte(?) treatment of the two groups, it needs to evaluate the clinical symptoms, signs of change, before and after treatment thyroid hormone and related observation antibody level, thyroid isthmu(?) thickness, tumor necrosis factor alpha (TNF alpha), etc. as well as patients’adverse reactions and compliance situation. All the data will be analyzed statistically with SPSS16.0statistica software.Results:The gender, age and course of disease of the two groups patients had no difference(?) pretreatment.1. The improving function of symptoms and signs:treatment group patients afte(?) treatment, symptoms were obviously improved, with the total effective rate was93.3%; The control group total effectiveness60%. The treatment group many TCM symptoms improve tha(?) those in the control group (P﹤0.01or P﹤0.05).2. The thyroid hormone levels:the treatmen group and control group TT3, TT4, FT3, FT4, TSH are significant difference (P﹤0.01); betwee(?) groups, the treatment group compared TT4, FT3, FT4levels rise significantly higher than that i(?) control group (P﹤0.01or P﹤0.05), TSH lower than in control group (P﹤0.05), with a statistica significance. TT3level is no obvious difference (P﹥0.05).3. Thyroid related antibody level, i(?) treatment group were significantly lower TGAb, TMAb, difference was statistically significan (P﹤0.01); the comparison in the group, the treatment group TGAb, TMAb group compared with a significant difference (P﹤0.01).4. After treatment with comparison before treatment, were markedly improved thyroid isthmus thickness, TNF alpha difference was statistically significan (P﹤0.01or P﹤0.05), and the treatment group thyroid isthmus of thickness and TNF alpha change than in control group (P﹤0.01).5. Safety indicators:Liver and kidney function tests were in the normal range. Both groups were no severe adverse reactions.Conclusion:The treatment group has significantly better effect on improving patients’subjective symptoms than the control group; the thyroid function, thyroid isthmus thickness, the improvement rate of TNF-alpha are prior to the control group; Chinese medicine treatment has function of regulating abnormal thyroid-associated antibodies (serum TGAb, TMAb) and has function of immune regulatory, it also has a certain significance for improving efficacy of hashimoto’s hypothyroidism, shortening duration and reducing the relapse rate. ErXianXiaoYing Prescription safe, effective, without any side effects.