The Study Of Zi Di Mixture And Finasteride On Decreasing Blood Loss In Patients Undergoing Transurethral Plasmakinetic Vaporization Prostatectomy

ObjectiveTo evaluate the effect of Zi Di Mixture and finasteride on intraoperative hemorrhage in patients with benign prostatic hyperplasia (BPH) treated by transurethral plasmakinetic vaporization prostatectomy (TUPKP)Methods45patienis with BPH were randomly and evenly divided into three groups, combined treatment group with Zi Di Mixture and finasteride, finasteride group and control group, and scheduled for TUPKP, patients in combined treatment group were received5mg of finasteride daily and50ml of Zi Di Mixture three times daily for sevendays before surgery, the finasteride group only were received5mg of finasteride for sevenday before surgery, the control group were not given any of above drugs, hemoglobin of intraoperative irrigating fluid were determined by the MetHb method. A serial clinical data of three groups were observed, calculated, recorded and statistically analysed.Resultsall45patienis finished the surgery successfully without transfusion of blood. In addition to no significant difference among weight of removal prostate in three groups, some other difference was discovered. Compared to control group, operate time, intraoperative irrigating fluid volume, amount of intraoperative bleeding, bleeding index in combined treatment group were significantly less (P<0.05),and obtained more operation efficiency (P<0.05). In addition, the significant difference of operate time,amount of intraoperative bleeding, bleeding index and operation efficiency also were observed between combined treatment group and finasteride group(P’<0.05). Yet, there were no significant difference in traoperative irrigating fluid volumeor between them(P>0.05). In finasteride group, only volume of traoperative irrigating fluid and amount of intraoperative bleeding were obvious less than control group (P<0.05).As paused delivery of the two drugs after TUPKP, there were no significant difference in postoperative irrigating time, postoperative irrigating fluid volume and the duration time of hematuria among three groups(P>0.05).ConclusionThe use of Zi Di Mixture and finasterid before TUPKP can reduce perioperative bleeding and increase operation efficiency.It is also no evidence to increase the risk of postoperative delayed bleeding.