Clinical Study Of Jianpihuayu Recipes Of TCM Combining Chemotherapy On Postoperative Recurrence And Metastasis Of Hepatocellular Carcinoma

Objective:Although hepatectomy for hepatocellular carcinoma (HCC) has become one of the most effective treatments, postoperative recurrence and metastasis are common and remain the main obstacle to long-term cure. The effect of chemotherapy alone in recurrent HCC has not yet obtained expectation. Traditional Chinese Medicine (TCM) has a long history in the treatment of HCC. Following the principle of "See the liver disease, liver spleen known biography, leading the spleen " in TCM, we prescribed jianpihuayu recipes of TCM combining chemotherapy in postoperative recurrent HCC. The objective was to investigate the influence of jianpihuayu recipes of TCM combining chemotherapy on recurrent HCC, to explore the mechanism of TCM on the treatment of recurrent HCC, to explore a new effective therapeutic schedule on recurrent HCC.Methods:We conducted a prospective randomized trial in patients with recurrent HCC, recruiting40recurrent HCC to undergo jianpihuayu recipes of TCM combining chemotherapy (treatment group) or to undergo chemotherapy alone(controlgroup). Liver function, serum alpha-protein(AFP), alpha-L-fucosidase (AFU), glucoprotein antigen19-9(CA19-9), ascites, and curative effect of the two group were analyzed.Results:1.AFP aspects:Before treatment, the two groups were compared, the t test, t=0.0712(P>0.05), the difference was not statistically significant, was comparable. After treated2,5,12months, the treatment group and control group AFP results respectively were401+88.6ng/ml and408±93.3ng/ml (t=0.8963, P=0.0378),312±63.2ng/ml and355+68.5ng/ml (t=2.1695, P=0.0364),268±53.4ng/ml and309±52.3ng/ml (t=2.4531, P=0.0189),(P<0.05),a statistically significant is difference.2.AFU aspects:Before treatment the two group were compared,the t test,t=0.7605,P>0.05,the difference was not statistically significant, was comparable.After treated2,5,12months,the treatment group and control group AFU results respectively were51±3.10u/l and50±3.91u／1(t=0.8963,P=0.0378),47±2.88u/l and45±2.95u/l(t=2.1695,P=0.0364),35±1.95u/land38±2.89u／1(t=3.8483,P=0.0004),(P<0.05),a staristically significant is difference.3.CA19-9aspects:Before treatment,the two groups were compared,the t test,t=1.0827,P>0.05,the diffeFerlce was not staristically significant, Was comparable.After treated2,5,12months,the treatment group and control group CA19-9results respectively were39±5.12u/mland43±5.67u/ml(t=2.3416,P=0.0245),35±4.86u/mland39±4.49u/ml(t=2.7036, P=0.0102),31±3.97u/mland34±4.03u/ml(t=2.3716,P=0.0229)(P<0.05), a statistically significant is difference.4.Liver function(ALT,AST,ALB,GGTP,TBIL,DBIL)aspects:Before treatment,the two groups were compared,the t test,t=0.7122,t=0.7612, t=1.0494,t=0.3066,t=0.8741and t=0.7174,(P>0.05),the difference was not statistically significant,was comparable.After treated2,5,12months, the treatment group and control group ALT,AST,ALB,GGTP,TBIL,DBIL results respectively were61±25.17u/1and76±19.85u／1(t=2.5878,P=0.0136),67±18.03u/l and83±16.32u/1(t=4.3499,P=0.0001),23±8.32g/l and18±7.18g/l(t=2.1944,P=0.0344),66±20.11u/l and82±27.82u/1(t=3.8476,P=0.0004),54±24.61μ mol／1and71±25.13umol/1(t=3.5755, P=0.0010)and21±6.34μ mol/1and26±8.55μ mol/l(t=2.8026,P=0.0079):46±16.34u／l and60±17.83(t=2.5888,P=0.0136),55±13.67u/l and72±14.75u/1(t=3.7804,P=0.0005),30±9.79g／l and24±8.37g/l (t=2.0833,P=0.0440),52±13.47u/l and67±17.65u/1(t=3.0213,P=0.0045),38±15.51μ mol/l and55±19.23μ mol/l(t=3.0773,P=0.0039)and15±4.58μ mol/1and19±6.87μ mol/1(t=2.1665,P=0.0366):32±12.21u/1and43±14.57u/1(t=2.5878,P=0.0136):41±9.56u/l and55±10.76u／](t=4.3499,P=0.0001),41±10.31g/1and34±9.86g／1(t=2.1944,P=0.0344),39±9.35u／l and52±11.87u／1(t=3.8476,P=0.0004),20±10.29u mol/l and33±12.59μ mol/l(t=3.5755,P=0.0010)and9±3.98μ mol/l and13±4.99(t=2.8026,P=0.0079)(P<0.05),a statistically signifiCant is difference. 5. Ascites aspects:Before treatment, the jianpihuayu recipes of TCM with the control group in ascites, Ridit analysis, u=0.8034,(P>0.05), the difference was not statistically significant, is comparable.After treat12months, comparison between groups, Ridit analysis, u=2.1848, P=0.0289(P <0.05), Show that by improve the patient the curative effect of Ascites jianpihuayu recipes of TCM is better than the control group.6. Curative effect:The treatment after12months, invigorate jianpihuayu recipes of TCM group total effectiveness60%, the control group total effectiveness60.5%, two group total effectiveness difference was statistically significant. But jianpihuayu recipes of TCM group in the ascites situation in stability in number is better than control group (6:3), in the deterioration in number is lower than that in control group (2:4).Conclusion:Jianpihuayu recipes of TCM combination chemotherapy treatment for recurrent hepatocellular carcinoma transfer can reduce the extent of damage of the liver function of chemotherapy, at the same time enhance immunity, improve the quality of life of the patients, which is a kind of treatment for recurrent hepatocellular carcinoma metastases are ideal treatment method.