Amplitude Of Low-frequency Fluctuation Study Of Resting-state Functional MRI In Vascular Cognitive Impairment No Dementia

Objective1.To explore the cognitive dysfunction characteristics of the vascular cognitive impairment no dementia (VCIND) after ischemic stroke by the neuropsychologicalscale.2.To explore the feature of brain activity changes in resting-state in patients w-ith vascular cognitive impairment of no dementia(VCIND) after ischemic stroke byamplitude of low-frequency fluctuation．Subjects1. The study choose convalescent patients after ischemic stroke of our neurolo-gy department from October2010to November2011.The general cognitive function-ns of the subjects were assessed by (Montreal Cogonitive Assessment,MoCA,Beijin-g Version) and (mini-mental state examination,MMSE). At last,20patients (Male13,Female7,Max age75,Min age55,Average66.91±7.21) with vascular cognitive imp-airment of no dementia(VCIND) were screened as experimental group;17patients(CVD)(Male9,Female8,Max age75,Min age55,Average65.82±5.58) with cerebr-ovascular disease without cognitive impairment were screened as CVD group;21h-ealthy older adults (Male12,Female9,Max age75,Min age55,Average64.87±6.13)were chosen as the cotrol group,who were age,sex,and education-matched with V-CIND. Three groups above were checked by neuropsychological scale.2. At the same time,14VCIND patients (male6,female8,Max age72,Min a-ge55, Average63.91±9.32) above from May2011to November2011were screen-ed as experimental group；13healthy older adults (male7,female6,Max age71,mi-nimum age55, Average62.87±7.26) were chosen as the cotrol group,who were age,sex,and education-matched with VCIND. Two groups above were checked by restin- gstate functional MRI.Methods1. Memory, attention, language ability, executive function and visual spatial ab-ility were investigated by using the neural psychological scale:mini-mental state exa-mination(MMSE),Montreal Cognitive Assessment(MoCA),ADAS－Cog,Verbal fluencytest(VFT),trail making test(TMT),Stroop Color Words Test(CWT)and so on.2.All the patients and healthy older adults underwent Sieens Sonuta3.0Tesla f-unctional MR examination in resting-state (TR=2000ms,TE=30ms, Flip angle=90°,Slices=31,Resolution=64×64) and T1-MPRAG sequence (TR=1900ms,TE=2.13ms,TI=900ms,Flip angle=9°,Resolution=256×256,Slices=176).The data preprocessing wasperformed using SPM5,the ALFF analysis was performed using REST software.Atwo-sample t-test was used to examine the differences of ALFF between the V-CIND group and the control group,and the XjView software was used to viewthe r-esults and the anatomical locations of the ALFF differences between the two groups,and the MRIcroN soft was used to display the results．Results1. The total points of MoCA、MMSE、ADAS-Cog、VFT、Digital fall back、Digital symbol-s conversion、TMT A/B、CWT and so on with VCIND are sig-nificantly lower than the CVD and the NC（P＜0.05）; visual space/executive funct-ionof MoCA and language project of MMSE with VCIND group was significantl-y lower than the other groups (P <0.05); naming, memory of MoCA and direction-nalpower of the MMSE have no significant difference in three groups (P>0.05).2.Compared with controls,significantly increased areas of ALFF in resting-stateof VCIND included left middle frontal gyrus,left lenticular nucleus shell, left infer-ior cerebellar peduncle, right middle frontal gyrus, right inferior frontal gyrus orbitalplane and the angular gyrus; significantly the decreased areas included right limb-ic lobe and the left lingual gyrus.Conclusions1.This study suggested that the VCIND group after ischemic stroke were signi-ficantly worse on general cognitive, for example,executive function, attention langua-ge and spatial function. 2.The method of fALFF can provide valuable information for the diagnosis orthe study of brain function change of VCIND patients after ischemic stroke.