Effects Of Three Components Of Pm2.5on Rat Cardiac Hemodynamic And Myocardial Tissue Ang â…¡Content In Tai Gang Area Of Tai Yuan

ObjectiveObserve the different components of fine particulate matter (PM2.5) to rat cardiac hemodyna-mic effects and Myocardial tissue Ang II content. Further explore the might factors of the different components of PM2.5to rat cardiac function change.MethodsWistar rats randomly are divided into four groups;①Organic Extract Group,OG;②Water Soluble Extract Group, WG;③Mixing Extract Group,MG;④ontrol Group; every rat of each group is tail intravenous at10days later,using PowerLab system records rats hemodynamic parameters and observe the effects. Using double antibody ABC-ELISA method to detect the homogenate angiotensin Ang II content in rats plasma and tissue.Results(1)10days after the rats of Water Soluble Extract Group and Mixing Extract Group are HR significantly faster. LVEDP increase,LVSP reduce,+dP/dtmax and dP/dtmax decrease;the rats of Organic Extract Group,LVEDP increase,+dP/dtmax and-dP/dtmax decrease,but HR.LVSP have no obvious change.(2) Compared with the control, each individual PM2.5rats, myocardial tissue homogenate Ang II content increased significantly and the plasma Ang II content level decreased (P<0.05).Conclusion(1) PM2.5Organic extracts enlarged LVEDP in rats, and decrease+dP/dt max and-dP/dt max; with no significant effect on HR and LVSP.(2) PM2.5Water Soluble extracts enlarged LVEDP,but accelerates HR,reduces LVSP、+dP/dtmax and-dP/dtmax。(3) PM2.5Mixture extracts enlarged LVEDP significantly,but accelerates HR.reduces LVSP^+dP/dtmax and-dP/dtmax。(4) The plasma AngⅡ content level was decreased and Cardiac muscular tissue AngⅡ content level was increased in PM2.5extracts-treated groups which is the possible mechanism to Cause rats hemodynamics abnormality.