The Efficacy Of Yasmin Compared With DIANE-35for Polycystic Ovary Syndrome

OBJECTIVE:To explore the efficacy of Yasmin compared with Diane-35for polycystic ovary syndrome (PCOS).METHODS:58women with PCOS were randomized to Yasmin(28patients) or Diane-35(30patients) for3months.Sex hormones, lipid metabolism、fasting blood glucose (FPG)、Fasting insulin (FINS)、HOMA-IR、and Body weight were compared after treatment.RESULTS:Testosterone levels、luteinizing hormone (LH) and Hairy symptoms were significantly decreased in the two groups(P<0.05) but did not differ significantly between these two groups after treatment(P>0.05). PCOS patients were given Yasmin and Diane-35treatment of three cycles after the two sets of body weight, body mass index (BMI) and waist-hip ratio (WHR) were notsignificantlychanged(P>0.05).High-density-lipoprotein(HDL),low-density-li poprotein(LDL),total-cholesterol(T-CHO)were significantly increased in Diane-35(P<0.05). HDL and T-CHO were significantly increased in Yasmin (P <0.05). and TG、LDL before and after treatment difference not statistically significant (P>0.05). Lipid parameters before and after treatment the difference was not statistically significant (P>0.05). Fasting plasma glucose (FPG) before and after treatment did not change significantly (P>0.05). Up to Diane-35 treatment, fasting insulin (FINS) and insulin resistance index (HOMA-IR) than before treatment was significantly higher (P<0.05); FINS and HOMA-IR decreased significantly(P<0.05)in Yasmin; FPG、FINS and HOMA-IR difference between the two groups before and after treatment was no significant difference (P>0.05).The side effects and medication satisfaction between Diane-35are quite.COMCLUSIONS:Yasmin and Diane-35can effectively improve PCOS hyperandrogenism, high LH endocrine environment and hirsutism symptoms, and had no significant effect on body weight.Diane-35may have a negative impact on lipid metabolism、fasting insulin levels and insulin resistance, adding to the PCOS existing lipid metabolism and glucose metabolism disorders, while Yasmin adverse effects on lipid metabolism, even for the beneficial effects; PCOS patients and can lower fasting insulin, reduce insulin resistance, PCOS is more conducive to long-term cardiovascular and cerebrovascular diseases and diabetes prevention.Recommend Yasmin treatment of disorders of lipid metabolism and glucose metabolism in patients with PCOS.