Degradation Of Biodegradable Ureteral Stent Composed Of Electrospun Nanofibers Implanted In Muscle And It’s Histocompatibility

BACKGROUND: The author has completed the preliminary investigation ondegradation of electrospun nanofiber poly lactic acid-glycolic acid copolymer (PLGA)biodegradable ureteral stent material in vitro and found the degradation time of80/20PLGAmaterial in urine could meet the clinical needs.OBJECTIVE: To investigate the degradation properties of80/20PLGA electrospunnanofiber ureteral stents implanted in muscle and the local tissue reaction in the degradationprocess.METHODS: The80/20PLGA electrospun nanofiber ureteral stents were prepared byelectrostatic spinning. The degradation properties of the stents and local tissue pathologicalreaction in rabbit paravertebral muscle were observed.RESULTS AND CONCLUSION: Electrospun nanofiber ureteral stents weresuccessfully prepared with a good morphology under scanning electron microscopy. At10weeks of degradation of80/20PLGA electrospun nanofiber ureteral stents, their mass was60%of initial mass, and fracture and disintegration of the stents occurred. Degradation rateof the stents was slightly decreased than that in vitro, but they were still able to meet theclinical needs of biodegradable ureteral stents. Peritubular muscle tissue shows a mildreversible non-bacterial inflammation in the early period. It has a promising clinicalapplication value.