| Objective：To research the blood lipid (total Cholesterol, triglyceride,high-density lipoprotein and low-density lipoprotein) and the renal function(creatinine and glomerular Filtration Rate), and analyze the relationship the levelof blood lipid and the renal function in patients with chronic kidney diseasewithout dialysis.Methods:124patients with chronic kidney disease without dialysis whovisited the nephrology department of our hospital in January2009and February2010were included in this research, and25healthy subjects who took physicalexamination in the same time were included as control. Total Cholesterol,triglyceride, high-density lipoprotein and low-density lipoprotein weredetermined by full-automatic biochemistry analyzer after venous blood in cubitswas collected from all the subjects before breakfast. Creatinine in serum wasdetermined by full-automatic biochemistry analyzer. glomerular filtration ratewas determined by renal dynamic imaging of99MTC-Pentetate acid andStannous Chloride, and cacultated by method of Gates. The blood lipid (totalCholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein)and the renal function (creatinine and glomerular filtration rate) were comparedin both patients with chronic kidney disease without dialysis and healthysubjects. The blood lipid level was compared in different creatinine andglomerular filtration rate in patients with chronic kidney disease without dialysis.The relationships of the blood lipid and renal function were studied by linear regression of total Cholesterol, triglyceride, high-density lipoprotein low-densitylipoprotein to creatinine and glomerular filtration rate.Results:124patients with chronic kidney disease without dialysis wereincluded in this research, in which there were67(54.03%) cases with primaryglomerulonephritis,44(35.48%) cases with hypertension,6(4.84%) cases withIgA glomerulonephritis,4(3.23%) cases with uarthritis, and3(2.42%) caseswith other pathogenesis. The levels of total Cholesterol, triglyceride andlow-density lipoprotein were significantly in patients with chronic kidneydisease without dialysis and healthy subjects in statistic (P<0.01), but the levelof high-density lipoprotein were not significantly in statistic. Creatinine andglomerular filtration rate were significantly in patients with chronic kidneydisease without dialysis and healthy subjects in statistic (P<0.01). Patients withchronic kidney disease without dialysis were divided into different groupaccording to glomerular filtration rate:21(16.94%) cases in I stage,31(25.00%)cases in II stage,29(23.39%) cases in III stage and24(19.35%) cases in IVstage, and19(15.32%) cases in V stage. Patients with chronic kidney diseasewithout dialysis were divided into different group according to Creatinine:41(33.06%) cases in the level of1-2,83(66.94%) cases in the level of3-5. Thelevels of cholesterol, triglyceride and low-density lipoprotein were significantlydifferent in patients with chronic kidney disease without dialysis of differentcreatinine and glomerular filtration rate (P<0.01). The levels of cholesterol,triglyceride and low-density lipoprotein were gradually increased with theincreased creatinine and glomerular filtration rate, but the level of high-density lipoprotein was not significantly different (P>0.05). The results of linearregression showed that creatinine was positively correlated to cholesterol,triglyceride and low-density lipoprotein (P<0.01), and not correlated tohigh-density lipoprotein (P>0.05); glomerular filtration rate were negativelycorrelated to cholesterol, triglyceride and low-density lipoprotein (P<0.01), andnot correlated to high-density lipoprotein (P>0.05).Conclusion:(1) The levels of cholesterol, triglyceride and low-densitylipoprotein in patients with chronic kidney disease without dialysis weresignificantly higher than those in healthy subjects;(2) The level of creatinine inpatients with chronic kidney disease without dialysis were significantly higherthan those in healthy subjects, but glomerular filtration rate in patients withchronic kidney disease without dialysis were significantly lower than those inhealthy subjects;(3) The level ofcreatinine in patients with chronic kidneydisease without dialysis was positively correlated to cholesterol, triglyceride andlow-density lipoprotein;(4) glomerular filtration rate in patients with chronickidney disease without dialysis were negatively correlated to cholesterol,triglyceride and low-density lipoprotein;(5) The disorder of blood lipid isclosely correlated with the aggravating of the renal function in patients withchronic kidney disease without dialysis, ant that is the risk factor of aggravatingof chronic kidney disease. |
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