The Relationship Of Serum Osteocalcin Concentration And Glucose Metabolism In Patients With Type2Diabetes Mellitus

[Objective]To investigate the correlations between serum osteocalcin and glucose metabolism in patients with type2diabetes.MethodsTotal osteocalcin, undercarboxylated osteocalcin, fasting blood glucose, fasting insulin, and HbAlc were determined in66cases of type2diabetes.Osteocalcin concentrations were compared between groups of different levels of HbAlc, and parameters of glucose metabolism were compared between groups of different levels of total osteocalcin and undercarboxylated osteocalcin. The relationship between Osteocalcin and parameters of glucose metabolism was also analyzed.[Results]The total osteocalcin concentrtaiton of high-HbAlc group was significantly lower than that of low-HbAlc group.The fasting plasma glucose of low-total-osteocalcin group was significantly higher than that of high-total-osteocalcin group in male participants, while the fasting plasma glucose of low-undercarboxylated-osteocalcin group was significantly higher than that of high-undercarboxylated-osteocalcin group in all participants. Total osteocalcin was inversely correlated with HbAlc, and undercarboxylated osteocalcin was inversely correlated with fasting plasma glucose. However, no significant correlation was found between osteocalcin and HOMA-IR. Total osteocalcin was an independent related factor in influencing HbAlc level.[Conclusions]Decreases of serum total osteocalcin and undercarboxylated osteocalcin both have close relations with the worsening of Glucose metabolism disorder, but have no relations with the insulin resistance.