| Background and objective:The morbidity rate of Diabetes mellitus (DM) and coronary heart disease (CHD) is rising each year. Diabetic nephropathy (DN) is most important complication of DM, coronary lesions in DM are more serious than patients without DM, which can impact patient’s health. Now coronary arteriography (CAG) and percutaneous coronary intervention (PCI) are wildly used in paitents with CHD. And the morbidity rate of acute kidney injure (AKI) is rising for using more contrast angent than before. Our study is anticipating observe about protection of renal function in patients with coronary heart disease wirh diabetes mellitus, after CAG and PCI.Materials and methods:We choice about60patients with coronary arteriography, and70patients with coronary intervention therapy, they are divide into2groups randomly. The first group they used20mg atorvastatin, the other patients used40mg atorvastatin. We Compared about CRP, Cys α1—MG, TRF, mALB and eGFR at before,1day,2days and5days. The comparison of the quantitative variables was performed by the t test. The statistical significance was determined using the exact P value. P<0.05was considered as significant.Results:We found that the levels of CRP, Cys C, α1—MG, TRF and mALB after CAG or PCI were higher than before in both groups (P<0.01). After CAG and PCI patients used20mg atorvastatin had higher levels of CRP and Cys C than before, and the same change had impression in α1—MG, TRF and mALB. And there were no change in Scr, eGFR (P>0.05). We found the same results in patients used40mg atorvastatin. The results showed that patients with CHD and DN, who used40mg atorvastatin, will get better protection of renal function than patients used20mg atorvastatin.Conclusion:We found that contrast can induced acute kidney injure after CAG and PCI. And atorvastatin can reduced acute kidney injure caused by contrast. We also found that patients taken40mg atorvastatin had more protection of renal function than patients used20mg atorvastatin. |
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