The Clinical And Pathological Analysis Of1447Cases Of Oral And Maxillofacial Malignancies

Background and ObjectiveOral and maxillofacial malignancies is an important part of the systemic malignancy in systemic malignancy in a very considerable proportion. China’s population base more, so the absolute number of China’s oral and maxillofacial malignancies in patients with still more. In addition, the anatomic site of the oral and maxillofacial relatively special, it difficult to treat relatively large, and oral and maxillofacial complex organizational structure, and a variety of diseases. In recent years, the incidence of oral and maxillofacial malignancies has improved, a part of the incidence of malignant tumors grew rapidly. In this study, nearly a decade through retrospective analysis of treatment in the First Affiliated Hospital of Zhengzhou University of oral and maxillofacial, Initially explore the characteristics of the disease, provide some clinical data and reference for the diagnosis and treatment of oral and maxillofacial malignancies of Henan Province. Materials and Methods1447cases of oral and maxillofacial malignant tumors collected nearly a decade treatment of the First Affiliated Hospital of Zhengzhou University, same patient with a malignant repeatedly hospitalized for a single case, the Birthplace of cases are in Henan. The classification of the clinical data in accordance with the classification of WHO2005tumor disease, installments based on AJCC seventh edition TNM staging. General statistics of1447cases cases, lesions, pathological diagnosis. The patients were divided into before and after five years, the two time periods to explore the incidence of the law. SPSS17.0software for statistical analysis using chi-square test was used for statistical tests, All results were statistically significant when P<0.05.Results1. Oral and maxillofacial malignancies average age was53.94±16.93years old, aged51-60years of age, peak incidence, aged41-80years old-prone age range; Oral and maxillofacial malignancies in the elderly the most common,followed by middle-age and young people. In addition, oral and maxillofacial malignant male to female ratio is1.3:1. While the incidence of part of the first six followed by the tongue, cheek, jaw, the parotid gland, gums, palate. Pathological type of the top five were squamous cell carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, malignant lymphoma, non-specific cancer.2. Salivary gland epithelial-derived malignancies average age was48.90±17.01years old, aged41-50years for the incidence peak, aged31-70years old-prone age range; the male to female ratio of0.97. The top five in the diseased parts were for the parotid gland, palatine gland, submandibular gland, buccal glands mandible (five years after the relative in the previous five years, the tongue glands, buccal glands, palatine gland, mandible, floor of mouth, the base of the tongue incidence ratio decreased, while the parotid, submandibular and sublingual gland, the incidence has risen). Before the pathological type of five followed by adenoid cystic carcinoma, mucoepidermoid carcinoma, non-specific adenocarcinoma, pleomorphic adenoma, squamous cell carcinoma. 3. Mesenchymal malignancies average age was34.79±19.65years old, The highest proportion of young people, followed by middle-aged and the elderly; male and female ratio of1.45:1; Incidence of part of the jaw and cheek more; pathological type of the top four followed by osteosarcoma,malignant fibrous histiocytoma, rhabdomyosarcoma,leiomyosarcoma.4. Oral and Maxillofacial average age was58.32±14.17years old, Aged51-60years of age for the onset of the peak, aged41-80years old-prone age range; the elderly, followed by middle-aged and young people,the male to female ratio of1.52:1.In addition, the predilection sites of tongue, gums, cheek, jaw, floor of mouth.5. Malignant lymphoma, the average age was51.86±21.92years old, male to female ratio of0.96:1, the diseased parts of the neck and parotid area.6. Oral and maxillofacial malignant melanoma, the average age of50.4years, the male to female ratio of1.09:1.39cases of oral mucosal melanoma disease sites were the palate, gums, cheek, lip; Compared to pathology, immunohistochemistry, pathology, HE staining pathology, pathological diagnosis including quick frozen, and simple HE staining pathology misdiagnosis rate was43.6%; Cases of melanoma of the oral mucosa and neck metastasis rate was79.4percent, the regional lymph node metastasis involving the frequency of the number47,30cases of Ⅰ-Ⅱ,12cases of Ⅲ,1case of Ⅳ, none of V,4cases of parotid gland.Conclusions1. The peak incidence of oral and maxillofacial malignancies of Henan Province aged51-60years old, multiple age range of oral and maxillofacial malignancies aged41-80years old; Elderly onset up to the male predominance; diseased parts of the tongue up to the cheeks, gums, palate and jaw are also common anatomical site Pathological type of squamous cell carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, malignant lymphoma, non-specific cancer more common.2. Salivary gland cancer incidence peak for the41-year-old-50years old multiple age range of31-year-old-70years old, more common in women; Diseased parts of parotid, palatine gland, submandibular gland and buccal glands; pathological type of adenoid cystic carcinoma, mucoepidermoid carcinoma, non-specific adenocarcinoma, pleomorphic adenoma, squamous cell carcinoma; Before and after five years compared to the incidence of minor salivary glands of decline in the proportion of major salivary gland disease has risen.3. Mesenchymal malignancy in young people the most, more common in men; diseased parts for jaw and cheek; pathological pattern was osteosarcoma, malignant fibrous histiocytoma, rhabdomyosarcoma, leiomyosarcoma.4. Squamous cell carcinoma of the peak incidence of51-year-old-60years old, multi-age range of41-year-old-80years old, the elderly, the largest male predominance; diseased parts tongue, cheek, gums, jaw, floor of mouth more common; before and after five In comparison, squamous cell carcinoma tended to increase.5. The incidence of malignant lymphoma parts of the neck and parotid region.6. Oral mucosal melanoma men were diseased parts common to the palate, gums, cheek, lip; in principle, should be held in the comprehensive treatment; pathological diagnosis of HE staining and immunohistochemistry, the combination to avoid misdiagnosis; cervical lymph node metastasis rate higher transfer located I Ⅲ District.