The Study Of Treating Patients Of Chronic Obstructive Pulmonary Disease With Invasive Mechanical Ventilation Using Bronchoalveolar Lavage

Objective: To study effects of bronchoalveolar lavage treating patientschronic obstructive pulmonary disease（COPD） with invasive mechanicalventilationMethods: 96 Patients with hypercapnic respiratory failure caused byCOPD, and on the basis of using invasive mechanical ventilation，was dividedinto have-phlegm-group and no-phlegm-group through regularly sputumsuctioning, have-phlegm-group randomly divided into two groups, group Awent go taking invasive mechanical ventilation, group B were givenbronchoalveolar lavage on the basis of mechanical ventilation every day;no-phlegm-group also randomly divided into two groups, group C went gotaking invasive mechanical ventilation,group D were given bronchoalveolarlavage on the basis of mechanical ventilation every day . Arterial blood gasindex （pH, PaCO2, PaO2）, the time of invasive mechanical ventilation,RICU-days, RICU hospitalization expense were measured before and afterinterventionResults: In the patients of have-phlegm-group，pH roughly returned tonormal range, PaCO2 decreased , PaO2 increased, The significance withintwo groups occurred earlier （P < 0.05）; on the aspect of outcome, the time ofinvasive mechanical ventilation、RICU-days and RICU hospitalizationexpense in group B were shorter than those in group A （P < 0.05）. In the patients of no-phlegm-group，pH also roughly returned to normal range,PaCO₂ decreased , PaO₂ increased, two groups were not significant duringthe whole intervention periods （P＞0.05）; on the aspect of outcome, the timeof invasive mechanical ventilation、RICU-days and RICU hospitalizationexpense in group D were shoter than those in group C （P＞0.05）Conclusion: In the have-phlegm-group，treatment using bronchoalveolarlavage can make patients with hypercapnic respiratory failure due to COPDdecrease PaCO₂，increase PaO₂, recover pH and shorted the time of invasivemechanical ventilation、RICU-days and RICU hospitalization expense thanthose using invasive mechanical ventilation only; In the no-phlegm-group，treatment using bronchoalveolar lavage can make patients with hypercapnicrespiratory failure due to COPD decrease PaCO₂，increase PaO₂, recover pHand shorted the time of invasive mechanical ventilation、RICU-days andRICU hospitalization expense than those using invasive mechanicalventilation only，but difference of two groups have no statistics significance，Must be further research.