Effects And Mechanisms Of New Billiopancreatic Diversion Surgery For Plasma Glucose And Blood Lipids In GK Rats

【AIM】To observe how New Billiopancreatic diversion (NBPD) surgery andDuodenal-jejunal bypass (DJB) surgery affect plasma glucose and blood lipidsin Goto-Kakizaki (GK) rats, explore the possible mechanisms involved.【METHODS】1、Thirty male GK rats were randomized equally into three groups: the firstgroup undergoing DJB surgery (DJB surgery group), the second groupundergoing NBPD surgery (NBPD surgery group) and the last groupundergoing a sham operation (sham operation group).2、Body weight was detected1week before surgery and1、2、4、6、12weeksafter surgery in the fasting state;fasting plasma glucose (FPG) and randomplasma glucose were detected1week before surgery and1、2、6、12weeks aftersurgery;oral glucose tolerance (OGTT) was detected1week before surgery and4、8weeks after surgery.3、Fasting serum blood lipids（cholesterol, Ch、triacylglycerol, TG、free fattyacid, FFA) were detected2week before surgery and4week aftersurgery;postprandial serum blood lipids （cholesterol, Ch、triacylglycerol, TG、free fatty acid, FFA) were detected1week before surgery and6、12weeks aftersurgery.4、Fasting serum insulin（INS）was detected2week before surgery and6week after surgery.【RESULTS】1、The body weights of DJB-treated and NBPD-treated rats were lower thansham operation groups1、2weeks after the surgery (p<0.05)and had nodeference compare with sham operation groups12weeks after the surgery(p>0.05). 2、The random plasma glucose of DJB-treated and NBPD-treated rats werelower than preoperative level and sham operation groups1、2、6、12weeks afterthe surgery (p<0.05). The fasting plasma glucose of these three groups were nodifferent after surgery. Eight weeks after the surgery the peak value incarbohydrate tolerance of DJB-treated descended and were lower than shamoperation groups(p<0.05).3、The fasting cholesterols of DJB-treated and NBPD-treated rats were lowerthan sham operation groups(p<0.05);.the fasting triacylglycerols of DJB-treatedand NBPD-treated rats were increased4weeks after the surgery and even morethan preoperation(p<0.05); The fasting free fatty acids of DJB-treated andNBPD-treated rats were lower than sham operation groups(p<0.05).6、12weeksafter the surgery the postprandial cholesterols and triacylglycerols of DJB-treatedand NBPD-treated rats were lower than sham operation groups(p<0.05), thepostprandial free fatty acids of three groups were not different(p>0.05).4、The serum INS of DJB-treated and NBPD-treated rats had decreasedcompare with sham operation groups(p<0.05).【CONCLUSION】Both DJB surgery and NBPD surgery can reduce plasma glucose and bloodlipids possibly due to the division of bile and pancreatic juice delay the mixtureof diet and bile and pancreatic juice,shift down the mixture place and affect thedigestion and absorb of diet.Besides;the decline of blood lipids may enhanceinsulin sensitivity to improve plasma glucose.