The Serum Levels And Significance Of FGF-23and Matrix Gla Protein In Maintenance Hemodialysis Patients

Objectives: The aim of this research was to study the FGF-23and the MGPexpression with the calcium,the phosphorus, and the1,25-（OH）₂D₃change bycompared serum maintenance hemodialysis patients and healthy controls, and studythe significance of FGF-23and the MGP expression to the hemodialysis patient’s.Methods: The patients group: Collected40cases of affiliated hospital of Qinghaiuniversity in maintenance hemodialysis patients, selected conditions:â‘ thehemodialysis time was more than three months;â‘¡noapplieddrugs that affect calciumand phosphorus metabolism, and no obvious infection, liver damage, malignancy,â‘¢Exclude primary disease of diabetic nephropathy and hypertensive nephropathy.All patients were treated with Fresenius4008S dialysis machine, Germany Bay longhigh flux dialyzer, Dialysis membrane area was about1.2m². polysulfone membranedialyzers （all were not used repeatly）, bicarbonate dialysis, dialysate calciumconcentration of1.25mmol/l,Every dialysis time is4hours and2-3times per weekinternal arteriovenous fistula. The control group: Healthy subjects40cases ofaffiliated hospital of Qinghai university, ruled out heart and lung disease, and thefunction to liver and kidney were normal. Laboratory tests: Patient and control groupswere given the fasting blood, the ELISA method for determine the level MGP andFGF-23.Radioactive immunizationlaw, radio-immunitym measuring the1,25-（OH）₂VitD₃level.Determination of calcium, phosphorus, creatinine level at the same timeusing the automatic biochemical analyze.Results:（1） FGF-23, MGP expression in hemodialysis patients were higher than thehealthy control group population （p <0.01）, but the1,25-（OH）₂D₃levels were lowerthan the healthy control group （p <0.01）.（2） Linear correlation analysis showed thatFGF-23was positively correlated with,MGP, creatinine, phosphorus, duration ofdialysis （p <0.01）, and inverse correlated with1,25-（OH）₂D₃（p <0.01）,There wasno significant difference with serum calcium.（3） Multiple reghression analysis: Theresults show MGP,1,25-（OH）₂D₃, phosphorus were dependent factors that affeced the FGF-23.Condusions:1.FGF-23,MGP level were higer in cases of hemodialysis patients thannormai controls,which were closely to calcium phosphorus metabolism disorder,phosphate deposition; Both are being connected with the high phosphoremia;2. MGPand FGF-23in patients with chronic renal failure in hemodialysis patients withcompensatory is high level expression;3.Although the FGF-23,MGP levels inhemodialysis patients were high erpression,the FGF-23,MGP in hemodialysis patientswere irreversible changes caused by multiple factors.