Odorless Sulfanylation Reactions And The Ring Opening Reactions Of Aziridines Under Green Conditions

Odorless sulfanylation4-hydroxycoumarins and the ring opening reactions ofaziridines with NaN3under green conditions were studied in detail.In part one, a green, efficient novel route for the synthesis of4-sulfanylcoum-arins was disclosed. The sulfanylation of4-tosyloxy coumarins and one–pot directsulfanylation of4-hydroxyl coumarins with alkyl halides and thiourea in PEG200-H₂O gave the corresponding4-sulfanylcoumarin in good to excellent yields. Thistransformation with good substrate generality performed in green solvent at roomtemperature under air atmosphere is highly effective.In part two, the ring opening reaction of aziridines with sodium azide in waterwas studied. The results indicted that the ring opening reaction of aziridines withsodium azide in water is a efficient route for the synthesis2-amino azid compounds.These reactions promoted by cationic surfactant of benzyl-dodecyl-dimethyl-ammonium chloride without adding any other catalyst in water.