Synthesis Of Nitro-Based Matrilysin Inhibitors

Matrix metalloproteinases(MMPs), are a family of structurally related zinc-development enzymes. If the MMPs is overexpress or activated in vivo, will due to degradation of the extracellular matrix(ECM), this will cause arthritis, periodontitis, malignant proliferation and metastasis, sclerosis. So, much attention has been paid to the MMPs inhibitor research.Now, the mammalian MMP family is known to include at least20enzymes. MMP-1, MMP-2, and M; MP-7are effective target enzymes for anti-cancer drug. Matrix metalloproteinase-7(matrilysin, MMP-7) have been identified that it secreted by the tumor cells, And it induce the tumor cells evolve to cancer cells. The MMP-7overexpress ion can discovery in malignancy of the esophagus cancer, liver cancer, stomach cancer, skin cancer, thymic carcinoma. MMP-7can activate proMMP-2for generate MMP-2. Thus conducive to the transfer of cancer cells. Therefore, The inhibition of MMP-7is an effective way to control tumor metastasis.In this article, we briefly describe about matrilysin and their inhibitor, we mainly discuss the synthesis of the matrilysin inhibitor with nitro group as zinc-bingding group.