The Functionality Of Amphiphilic Block Polymer

Recent years, amphiphilic block copolymers have numerous application possibilities in many hot research areas like biomimetic mineralization, nanomaterials (L-B membranes), biomaterials, drug/gene delivery system and so on. Thus, the molecular design, synthesis, and self-assembly behavior have been deeply researched. By molecular design and controlling of the external environment, nearly each self-assembled mophorlogy can be got. Based on this, the applications are important topics. In this thesis, temperature and pH sensitive amphiphilic block copolymers have been synthesized and the functionalization is researched. The relatively detailed summaries were as follows.1. The synthesis of the amphiphilic block copolymers has been preliminarily improved. Normaly, the suspension of potassium naphthalene was used to initiate the synthesis. This is not easy to quantitatively determined, and is not good to be applicated in industry. This thesis replaced potassium naphthalene with solide potassium t-butoxide. Thus, the amount could be conveniently fixed and could also be conveniently stored.2. We obtained AB type amphiphilic block copolymers with tert-amino group through the oxygen cationic polymerization method. Afterwards, functionalized block copolymers with a biotin end group were obtained by reacted with activated biotin, which was biotin-NHS. The self-assembly behavior in water was characterized. Since Biotin has very strong specific interaction with avidin, once the medicine has been bundled in the fuctionalized micelle with biotin group, it could be easily targeted to the organization with avidin.3. We also designed the BAB type block copolymer, in which "B" referred to DMAEMA or DEAEMA segment, and "A" referred to PEO segment. The self-assembly behavior was carefully discussed, since the polymers were thermo-and pH-sensitive.4. Besides, our group has a long time interest in the catalyst. This thesis supposed that block copolymers have a new application:as a highly effective, easily separated, and recyclable heterogeneous catalyst. The copolymer was complexed with CuCl2, and was used in the aero-oxidation of TMP to TMBQ.The synthesis of PDMAEMA-PEG-PDMAEMA diblock copolymers by oxygen anion polymerization, the synthesis of biotin-PEG-PDMAEMA, and the functionalization of PDMEMA-PEG-PDMAEMA to be used as a highly effective, easily separated, and recyclable heterogeneous catalyst in the aero oxidation of TMP to TMBQ, to our best knowledge, are unprecedented.