Analysis Of178Cases Endometrial Cancer Clinical And Recurrence Factors

Objective: In recent years, with the improvement of economic andmedical technical level, the extension of human life and sex hormone drugapplications, the incidence of endometrial cancer is on the rise and gettingyounger. In Europe and the United States, the incidence of endometrial cancerrate has become the first of the female reproductive tract. That is a seriousimpact on patient quality of life and health. In our country endometrial cancercases also increased rapidly now and should be brought to people's attention.This study analysis of endometrial cancer clinical and recurrence factors, inorder to estimate the prognosis of the disease and adopt effective measures toimprove the rate of survival.Methods:Retrospective analyzed178cases data about the endometrial cancer onclinic, pathology and follow up in our hospital from April.2008to May.2010.Depend on whether recurrence dividing into Group non-recurrence (162cases)and Group recurrence (16cases). The patient's general medical history,auxiliary examinations, treatment, pathological data filter were collected andrecorded into a database by us. We analyze and descriptive the collectedinformation by statistics using excel software, and examine the data withstatistical analysis using SPSS17.0software. Measurement data is expressedin the form of Mean±Standard deviation, and compared with t-test.Enumeration data is expressed in the form of ratio, compared with χ2test. Thestatistically significant difference is indicated by P<0.05.Results:1The age of patients is between28and77years old, with an average ageof55.7±9.10years. The median age is56years old. Overall age distribution ofpeak is56to60years. 2There are155cases with clinical symptom of irregular vaginal bleedingand12cases complained the vaginal drainage and11cases have abdominalpain or other symptoms.60cases have complications of high blood pressure,diabetes,62cases combined with obesity.3There are97cases in stage Ⅰ,49cases in stageⅡ,27cases in stage Ⅲand5cases in stage Ⅳ. There are149cases of endometrial adenocarcinomaand the mixed carcinoma in12cases, other cancer types (including clearadenocarcinoma papillary gland adenocarcinoma, undifferentiated carcinomas,and squamous adenocarcinoma)17cases. There are25cases of low celldifferentiation and153cases of middle and high differentiation. Preoperativestaging a error rate about20.7%in stage Ⅰ,29.7%error rate in stageⅡ; errorrate27.3%in stage Ⅲ, Ⅳphase error rate by25%.4Age, clinical Pathologic stage, cell differentiation, organization type,myometrial invasion, lymph node metastasis, attachment transfer, vaginaltransfer, progesterone receptor expression and vascular tumors are allinfluencing factors of recurrence, by chi-square test, P <0.05. The studyinvolved after statistics cervical tube situation inspection and recurrence noobvious related, P>0.05.5The recurrence rate is9.0%.56%cases recurrence in1year and87.5%recurrence in two years,37.5%of patients with recurrent die within two years.Basin for common abdominal relapse and metastasis place, followed by thelung and the bone.Conclusions:1There are significant differences with major clinical symptom ifpatients weather postmenopausal.2There is a certain error between endometrial carcinoma with surgicalpathology staging and clinical stage, preoperative clinical stage should payhigh attention. Surgical pathology is more accurate than clinical stage, andplay a positive role in guiding to objective prognosis, and further treatment ofpostoperative. 3In this study, endometrial cancer recurrence rate is9.0%.56%patientsrelapse within1year of the and37.5%of the recurrence patients died, withshort survival time. Common relapse and metastasis parts of abdominal basin,the second is in the lung and the bone.4There are no significant differences between diabetes, high bloodpressure, obesity and recurrence endometrial cancer.5Age, clinical Pathologic stage, cell differentiation, specialorganization type, deep myometrial invasion, lymph node metastasis,attachment transfer, vaginal transfer, progesterone receptor expressionnegative and vascular tumors are all influencing factors of recurrence.Improve the understanding of the relationship between the above factors isgood to clinical prognostic and treatment at a guidance and improve thequality of life of the patients and the survival rate.6Lymph node can metastasis readily to PALN. While isolated PALNmetastasis rate occurred in only6.25%(1/16).7In this study, the number of cases are less and time is short. We stillneed to continue to accumulate material for further research.