<sup> 18 </ Sup> F-FDG Coincidence HPET / CT Imaging Combined With Tumor-associated Antigens In Solitary Pulmonary Nodules Diagnosis Of Benign And Malignant Applications

[Objectiv] Explore the18F-FDG coincidence line hPET/CT imaging combined with the clinical value of tumor-associated antigen identified diagnosis of lung disease in benign and malignant.[Methods] Select in July2010, January2012, Kunming Medical College, Second Affiliated Hospital of Respiratory Medicine and Thoracic Surgery hospitalized patients in the hospital radiology CT scan found a solitary pulmonary nodules, after the Undergraduate line18F-FDG in line withline hPET/CT imaging examination in patients with eligible56patients. And blood samples of56patients blood to the tumor-associated antigen of CYFRA21-1, NSE, and CEA, the imaging results with tumor-associated antigen.18F-FDG imaging and tumor-associated antigen CYFRA21-1, NSE and CEA in the diagnosis of lung cancer.[Results]1.T/N is a commonly used semi-quantitative method, the T/N ratio of target and non-target tissue average radioactive. In56cases, the age span of45-89years old, male39, female17cases, metabolic imaging of18F-FDG T/N ratio of1.2-19.4, with an average1.8±3.5in the pathological diagnosis of malignant lesions42cases, lesions of the T/N ratio of1.8-19.4, average5.3±4.3, while the pathological diagnosis of14cases negative, lesion T/N ratio of1.2-8.5, an average of1.5±0.5, the coincidence rate with clinicopathological91.07%(51/56). Malignant lung lesions, sensitivity of95.23%(40/42) and a specificity of71.43% (10/14), accuracy of89.29%(50/56), positive predictive value of90.91%(40/44), negative predictive value83.33%(10/12)2. Tumor-associated antigen of CYFRA21-1, NSE, and CEA in the blood samples of56patients, this study of42cases of lung cancer three markers measured values and non-lung cancer group,14cases measured by the statistical analysis, with a very significant difference (P<0.01), indicating that its lung cancer diagnostic significance.[Conclusion]18F-FDG coincidence circuit hPET/CT imaging combined with clinical value of tumor-associated antigen of CYFRA21-1, NSE and CEA in the diagnosis of solitary pulmonary nodule higher.