| Objective:To analyze the relationship between the quality of life of patients and the general influence factors and clinical objective indicators among patients with chronic obstructive pulmonary disease (COPD); To evaluate the quality of life of patients with COPD and clinical objective indicators and changes in quality of life and their mutual relations by applying instruments of chronic diseases Quality of Life of Chronic Obstructive Pulmonary Disease (QLICD-COPD) for providing a basis of assessing the condition of patients with COPD and drug efficacy by using QLICD-COPD; To explore the significance of score changes of quality of life of patients with COPD.Methods:Using QLICD-COPD Scale, we collected patients with acute exacerbation of COPD with124cases in the First Affiliated Hospital of Kunming Medical College, breathing Division Two from September2010to July2011and evaluated their quality of life and general influence factors; To design the experimental group and control group and observe two sets of clinical objective indicators, the QLICD-COPD scores of changes and their correlation before and after tiotropium inhalation intervention. Statistical methods included statistical description, independent samples t test, analysis of variance, rank sum test, simple linear correlation analysis or multiple linear correlation and regression analysis throughout the study.Results:(1) By analysis of Quality of life scores of patients with AECOPD and general influence factors, the results show simple linear correlation in the general influence factors and ihc quality of life standards is not strong; Multiple linear regression showed age, lung umelion, educational level, economic status, body mass index had gone into the regression equation of the different fields and revealed that different general impact factors was different on the role of the quality of life. (2) The analysis of clinical objective indicators, change in quality of life score and their correlation showed that FEV1%pre, PaO2, CRP, the physical domain score, psychological domain score, the specific module score, the total standard score of the difference were statistically significant between the experimental group and control group after treatment; and the results of multiple linear stepwise regression analysis among FEVi%pre, PaO2, CRP difference and the difference between the total standard score of quality of life before and after the treatment of the experimental group showed that FEV1%pre, PaO2went into the regression equation and there were strong relationship between the above indicators and total standard score of quality of life.(3) Feasibility:the completion of the scale of the time required is generally between15-20minutes. The questionnaire recovery rate was93.9%, and completion rate of the questionnaire was95.7%, so the scale has good clinical feasibility.Conclusion:The general impact factors can not replace the QLICD-COPD scale, and there were strong correlation between the QLICD-COPD scale in all areas and age, FEVi%pre, education level, economic status, body mass index, so take these factors into consideration in assessment of the condition of patients by QLICD-COPD scale. QLICD-COPD scale is better and more comprehensive and more sensitive than traditional clinical indicators on the reflection of the drug effects, so QLICD-COPD Scale may not only be used to assess AECOPD disease, evaluate the effect of drug treatment, and more superior than objective indicators. |
PDF Full Text Request