A Retrospective Comparative Study In Laparoscopic And Open Adrenalectomy For Adrenal Pheochromocytoma

Objective:To compare the clinical efficacy and evaluate the clinical value of laparoscopic adrenalectomy and open adrenalectomy in treating adrenal pheochromocytoma.Methods:From April2008to May2011. we retrospectively analyzed the data of101patients treated for pheochromocytoma,49of cases received laparoscopic and other52cases underwent open surgery. The operation time, blood loss, transfusion rate, drainage duration, postoperative recovery of intestinal function of time, hospital stay, follow-up time, postoperative blood pressure return to normal rate, recurrence rate, complication, intraoperative hemodynamic parameters, incidence of intraoperative hemodynamic instability were compared between the two groups.Results:(1) Laparoscopic group had shorter operative time|(99.35±36.20) min vs. (154.54±74.98) min, P<0.05]; less intraoperative blood loss[(50/100-20) ml vs.(300/587.5-200) ml, P<0.05]; less transfusion rate[8.2%(4/49) vs.30.8%(16/52), P <0.05]; shorter drainage duration[(3.08±1.47) d vs.(4.98±2.13) d, P<0.05]; shorter postoperative recovery of intestinal function of time[(2.2±0.68) d vs.(3.63±1.20) d, P<0.05]; shorter hospital stay[(5.79±1.89d vs.(10.84±±4.63) d, P <0.05]when compared with open surgery group. No significant difference was found in follow-up time, postoperative blood pressure return to normal rate, recurrence rate, complication, intraoperative hemodynamic parameters, incidence of intraoperative hemodynamic instability between the two groups (P>0.05)(2) Comparison of different tumor diameter size in the laparoscopic group:No significant difference was found in operation time, blood loss, transfusion rate, drainage duration, postoperative recovery of intestinal function of time, hospital stay, complication, intraoperative hemodynamic parameters, incidence of intraoperative hemodynamic instability between the two groupsConclusions:To those experienced and skilled operators, laparoscopic adrenalectomy for pheochromocytoma is a safe and effective method, tumor size is not surgical contraindications, and will not increase the specific risks compared with open surgery. Since its minimal invasion and quicker recovery, laparoscopic adrenalectomy for pheochromocytoma should be considered as the first choice.