The Study Of Association Between Blood Test And The Outcome Of Patients With Paraquat Poisoning

Objective: Paraquat is a kind of herbicide which had great toxicity for people, and there is no specific antidote. The mortality of oral poisoning by paraquat is more than 60%. There is no prognostic marker for judging the outcome of paraquat poisoning at present. This retrospective study aims to finding the prognostic markers from blood test of patients after 1, 3, 5-day of paraquat poisoning.Bcakground: Paraquat poisoning is characterized by lung injury, also liver, kidney and central nervous system injury in acute phase, even multiple organ failure. Blood chemical examination usually displayed the variations of white blood cell counts, C-reactive protein, prothrombin time and so on.Methods:One-hundred Patients with paraquat poisoning hospitalized in 307 hospital form 2006 to 2008 were enrolled in this study. Egihteen patients that failed to follow up were excluded from the death record. Other patient were divided into two groups by survival (n=50) and non-survival (n=32). White blood cell counts, supersensitivity C-reactive protein, prothrombin time and blood gas analysis after 1, 3, 5-day of paraquat poisoning were compared between the two groups. Logistic regression and t-test were performed with SPSS version 10.0 for Windows software.Results: 1. White blood cell counts after 1, 3, 5-day of paraquat poisoning, C-reactive protein and prothrombin time after 3, 5-day of paraquat poisoning in non-survival group were significantly increased compared with survival group(P<0.05). 2. AMY, AST, Cr after 1, 3, 5-day of paraquat poisoning, TBIL and BUN after 3, 5-day of paraquat poisoning in non-survival group were significantly increased compared with survival group(P<0.05). 3. After 1, 3, 5-day of paraquat poisoning, the differences in PH, PE, HCO3 between the two groups were significan(tP<0.05). The significant differences in PO2 and PCO2 were only existed in 3-day and 1-day between the two groups after paraquat poisoning, respectively. 4. Logistic regression showed that none of these blood test markers was prognostic indicator which can predict the outcome ofparaquat poisoning.Conclusion: White blood cell counts, C-reactive protein, prothrombin time and blood gas analysis, AMY, AST, Cr, TBIL and BUN were all associated with the severity and outcome of paraquat poisoning, but none of them was a independent prognostic indicator. More samples multicentre studies are needed for further verification.