| ObjectiveIn this study, we tested the hypothesis that remote ischemia postconditioning induced by a single 5-min episode of renal artery occlusion and reperfusion applied immediately before the onset of superior mesenteric artery reperfusion protects the intestinal from reperfusion injury.MethodsThirty healthy New Zealand white rabbits were randomly divided into three groups(n=10 in each group):control, intestinal ischemic reperfusion (IR), and renal ischemic postconditioning (RIP). Tissue myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels were determined and the morphology of some intestinal tissues was observed by microscopy at the end of the experiment.ResultMDA levels and MPO activity was significantly steped up in IR and RIP as compared to control (p<0.01),also was confirmed by the score of intestinal mucosal injury.Conclusionrenal postconditioning provides potent intestinal mucosal injury. The potential mechanism of remote postconditioning might be associated decreasing the injury caused by oxygen free radicals and strengthening the action of antioxidation. |
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