Transforming Growth Factor-¦Â1 (tgf-¦Â1) And Its Receptor Of T¦Âr-i Of T¦Âr-ii Expression In Epithelial Ovarian Cancer

Objective To detect the expression of transforming growth factor-β1 (TGF-β1) and its receptorⅠ(TβR-Ⅰ) and receptorⅡ(TβR-Ⅱ) in epithelial ovarian cancer and its linicopathologic features and prognosis.Method Method Immunohistochemistry (IHC) was performed to detect the expression of TGF-β1, TPR-Ⅰand TβR-Ⅱin 59 cases of epithelial ovarian cancer,35 cases of benign epithelial ovarian tumor and 32 cases of normal ovarian tissue, and analyze them with the relationship between clinical and pathological factors.Results 1.TGF-β1 had a higher positive expression rate (69.2%) in epithelial ovarian cancers than benign ovarian tumors (47.2%) and normal ovarian tissues (21.1%), positive expression rates of TGF-β1 and TβR-Ⅱin epithelial ovarian tumors (59.3%,39.1%) were significantly lower than those of benign ovarian tumors (85.7%,67.1%) and normal ovarian tissues, the differences were statistically significant (P<0.05).2. In epithelial ovarian cancer tissues, the positive expressions of TGF-β1, TβR-Ⅰand TβR-Ⅱwere relevant with clinical stage and lymph gland metastasis (all P values were< 0.05), TGF-β1's positive expression was irrelevant with the histological grade (P>0.05), positive expressions of TβR-Ⅰand TβR-Ⅱwere relevant with histological grade (all p values were<0.05), positive expressions of all these three were irrelevant with age, pathological type (all p values were> 0.05).3. Positive expression of TGF-β1 in StageⅢ～Ⅳof epithelial ovarian cancer tissues were significantly higher than those of StageⅠ～Ⅱ(P<0.05); in epithelial ovarian cancer tissues with lymph node metastasis, positive expression rate of TGF-β1 was lower than that in the tissue without lymph node metastasis (P<0.05).4. Positive expression rates of TβR-Ⅰ, TβR-Ⅱin the well-differentiated epithelial ovarian cancer tissues were significantly lower than that of poorly and moderately differentiated ovarian cancer tissues (all P values were< 0.05); positive expression rates of stageⅢ～Ⅳof epithelial ovarian cancer tissues were significantly lower than those of stageⅠ～Ⅱ(all P values were<0.05); in epithelial ovarian cancer tissues with lymph node metastasis, the positive expression rate was lower than tissues without lymph node metastasis (all P values were< 0.05).Conclusions 1. In epithelial ovarian cancer tissues, positive expression rate of TGF-β1 was significantly higher than that of benign ovarian tumors and normal ovarian tissues, positive expression rates of TβR-Ⅰand TβR-Ⅱwere significantly lower than those of benign ovarian tumors and normal ovarian tissues, indicating that TGF-β1, TβR-Ⅰand TβR-Ⅱwere involved in the occurrence and development of ovarian cancer progress.2. In ovarian cancer tissues, the high positive expression rate of TGF-β1, and the low positive expression rates of TβR-Ⅰand TβR-Ⅱrespectively were relevant with clinical stages and lymph node metastasis, suggesting that the clinical testing of TGF-β1, TβR-Ⅰand TβR-Ⅱmay be helpful for determining the clinical stages of ovarian cancer, lymph node metastasis and prognosis evaluation.