Effect Of Adefovir On Portal Vein Hemodynamics Of Patients With Liver Cirrhosis After Hepatitis B

China is the region of a high incidence of hepatitis B virus infection, about 25-40% of patients would eventually deteriorate into cirrhosis. One of the main complications of liver cirrhosis is the portal hypertension. Because the high risk and the high cost of liver transplant surgery, then not all patients with portal hypertension can do liver transplantation. The traditional surgical devascularization and surgical shunt operation not only can not solve the problem of liver cirrhosis, but also may have an adverse effect on the operation of liver transplantation, so it has some limitations. In addition, the traditional medical therapy which has more limited application on the acute bleeding cases can not solve the problem of liver cirrhosis fundamentally, then it is easy to lead to recurrent bleeding. This study was to investigate the effect of the long-term use of adefovir therapy on the portal vein hemodynamics system in patients with liver cirrhosis of hepatitis B, then to find the more scientific and reasonable treatment way and theoretical basis for learning vein hemodynamics and treating the liver cirrhosis effectively, and thus guide clinical practice more rationally.Objective:To investigate the effect of the long-term use of adefovir therapy on the portal vein hemodynamics system in patients with liver cirrhosis of hepatitis B, then to find the more scientific and reasonable treatment way and theoretical basis for learning vein hemodynamics and treating the liver cirrhosis effectively, and thus guide clinical practice more rationally.Methods:52 cases with Hep B cirrhosis were divided into compensated group and uncompensated group,Both groups were treated by adefovir (10mg po qd) for 2 years. Before and after therapy, the spleen thickness and the parameters of portal vein (PV) including the inner diameter, the blood flow rate and the volume of blood flow were measured with GEvivid7 color doppler ultrasonography in all patients.Result:Before and after treatment of the compensated liver cirrhosis group, the spleen thickness were (5.0±.6) cm and (4.2±1.2) cm(t= 20.463,P<0.01), the inner diameter were (1.42±0.32) cm and (1.34±0.24)cm(t= 20.884, P< 0.01), the blood flow rate were (12.62±.23) cm/s and (13.74±2.33) cm/s(t=-14.736, P< 0.01),and the volume of blood flow of portal vein were(1192.67±312.33) ml/min and(1152.75±297.41) ml/min (t= 5.825, P<0.01); Of the uncompensated liver cirrhosis group, the spleen thickness were (6.4±1.8) cm and (6.4+1.9) cm (t=-0.395,P>0.05), the inner diameter were (1.57±0.36) cm and (1.58±.37) cm(t= 0.360, P>0.05), the blood flow rate were (11.25±2.11) cm/s and (11.32±2.24) cm/s(t=-1.081. P>0.05).and the volume of blood flow of portal vein were(1305.66±315.22) ml/min and (1317.34±320.14) ml/min (t=-0.213. P>0.05).Conclusion:After long-term adefovir therapy. The portal vein hemodynamics were significantly improved in patients with compensated liver cirrhosis resulting from chronic hepatitis B:The portal vein hemodynamics were not improved in patients with uncompensated liver cirrhosis resulting from chronic hepatitis B. patients with compensated liver cirrhosis resulting from chronic hepatitis B should be early treatment.