Analysis Of Clinical Pathological Factors Related To The Prognosis Of Patients With Stage â… b To â…¡b Cervical Cancer

Objective:To analyze the clinical pathological factors related to the prognosis of patients with stage I b to II b cervical cancer.Method:The 263 patients with stageâ… b toâ…¡b cervical cancer undergoing radical hysterectomy and pelvic lymphadenectomy were studied to obtain the exact clinical pathological data and follow-up data.The 13 clinical pathological factors such as age, tumor stage, the degree of cell differentiation, tumor histological type, depth of stromal invasion of the cervix, parametrial tissue involvement, uterine body involvement, tumor size, LVSI, lymph node metastasis, leukopenia,anemia, and adjuvant therapy were analyzed and balanced to screen the prognostic factors for cervical cancer. Statistical analysis:survival statistics was done using survival analysis method of Kaplan-Meier and Log-rank test,prognostic factors analysis was done using Cox proportional hazards model, and using SPSS 19.0 statistic software complete the operation.Result:The cumulative 5-year survival rate of the 263 patients with stage I b to II b cervical cancer was 75.7%.The result of single-factor analysis suggested that clinical stage,the degree of cell differentiation,depth of stromal invasion of the cervix,parametrial tissue involvement, and lymph node metastasis were the related prognostic factors of patients with stageâ… b toâ…¡b cervical cancer (P <0.05).Compared with the cases with iliac nodes, obturator nodes, or inguinal lymph nodes involved,cases with common iliac lymph nodes metastasis had poorer prognosis (P<0.05).Cases with four or more lymph nodes involved had poorer prognosis than those with three or fewer lymph nodes involved (P<0.05),while there was not significant difference on prognosis between the cases with one lymph node involved and the cases with two or three lymph nodes involved. Using multivariate Cox proportional hazards model regression analysis, non-squamous histological type,poor tumor cell differentiation, parametrial tissue involvement, and outer 1/3 stromal invasion were found to be independently related to patients'poor survival.(P<0.05).Conclusion:Clinical stage, the degree of cell differentiation,depth of stromal invasion of the cervix,parametrial tissue involvement, and lymph node metastasis are the related prognostic factors of patients with stageâ… b toâ…¡b cervical cancer. Non-squamous histopathologic type,poor cell differentiation, parametrial tissue involvement, and outer 1/3 stromal invasion are the independent poor prognostic factors for patients with stageâ… b toâ…¡b cervical cancer.