| Objective: To explore the relationship between the severity of heart failure and the changes of thyroid hormone and peripheral white blood cell count in acute myocardial infarction(AMI),we investigated their changes in patients with acute myocardial infarction.Method: According to Killip classification and EF%, 70 AMI patients were divided into two groups:heart failure32 case,non heart failure38 case.At the same time we choosed 50 patients with unstable angina and 53 health people as control.Thyroid hormone level and leukocyte count were detected and compared in them.Correlation analysis was conducted in the serum free triiodothyronine and leukocyte level and Killip classification in patients with acute myocardial infarction.Correlation analysis was conducted in the serum of patients with acute myocardial infarction free triiodothyronine and WBC.Result:The serum free triiodothyronine(FT3) level in patients with AMI was significantly decreased than in unstable angina(UA)and controls(3.41±0.78 VS 4.04±0.69 VS 4.25±0.56)(P<0.05); The serum free triiodothyronine(FT3) level in patients with UA was also lower, but not significantly than controls(4.04±0.69 VS 4.25±0.56)(P>0.05),there were no significant differences for the free thyroxine(FT4)(17.27±3.11 VS 16.27±2.13 VS 16.37±2.08 ) and thyrotropic-stimulating hormone (TSH) (1.76±1.54 VS 2.23±1.42 VS 2.15±1.34) levels in three groups(P>0.05)The serum free triiodothyronine(FT3) level in AMI patients with heart failure was lower than without heart failure(3.02±0.68 VS 3.74±0.72)(P<0.05).Acute myocardial infarction with low FT3 prevalence rate was significantly higher than normal FT3 in heart failure patients(70.8% VS 32.6% ) (P<0.05) .The Killip classification negatively correlated with free triiodothyroninein in the patients of acute myocardial infarction (r=-0.549,P<0.05).Leukocyte level in patients with AMI was significantly increased than in unstable angina(UA)and controls(9.04±3.63 VS 6.11±1.39 VS 5.95±1.37)(P<0.05);there was no significant difference in unstable angina and controls(6.11±1.39 VS 5.95±1.37 )(P>0.05);In patients with AMI and heart failure WBC was higher than without heart failure(10.22±3.89 VS 8.05±3.12)(P<0.05);Acute myocardial infarction with high leukocyte count prevalence rate was significantly higher than normal leukocyte count in heart failure patients(74.1% VS 27.9%)(P<0.05).The Killip classification positively correlated with leukocyte count in the patients of acute myocardial infarction (r=0.471,P<0.05).The change of free triiodothyronine negatively correlated with WBC in the patients of acute myocardial infarction(r=-0.354,P<0.05).Both of them were no correlation between UA and controls.Conclusion:1. Acute myocardial infarction and heart failure accompanies with low T3 syndrome and high white blood cell viremia . Both of them are independent risk factors for acute myocardial infarction.2. The change of thyroid hormone negatively correlates with WBC in the patients of acute myocardial infarction.3. These findings suggest that serum thyroid hormone levels and leukocyte count can be used for early identification of AMI and heart failure,and then take positive intervention so that patients have a better prognosis. |
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