The Research On The Effect Of Wu-Shen Oral Liquid On Diabetes Mellitus And Coronary Angina Pectoris

Diabetic coronary heart disease is one of the major and common diabetes complications. As diabetes has various impacts on human heart, and currently no method or index can help diagnose diabetic coronary disease at an early stage whether in home or abroad, plus no effective medication for diabetic coronary disease has been developed yet, it bares great importance to carry out further studies on this disease, aiming at exploring the rules for its diagnosis and cure, so as to develop effective formula to prevent diabetic coronary disease and ease the severity of the conditions.Objective:To find out the mechanism of the stenocardia to Diabetes mellitus and coronary heart disease by Wu-Shen oral liquid.Methods:80 Wistar rats only randomly divided into normal controls, model control group, Isoket group, Glimepiride group, Wu-Shen oral liquid small dose group, Wu-Shen oral liquid large dose group. In addition to the normal control group, Make the rest of the group diabetes mellitus and HyPerliPemia model With the Phago-source, and give the Pituitrin by vein injection to evoke the acute Myoeardial ischemia model。Then give different treatment, observe the mechanism of Wu-Shen oral liquid on biochemistry and Pathological histology. The Experimental rats diabetes mellitus and HyPerliPemia model With the Phago-source,and give the Pituitrin by vein injeeion to evoke the acute Myoeardial ischemia model。Then give different treatment,observe the mechanism of Wu-Shen oral liquid on biochemistry and Pathological histology.Results:1.Wu-Shen oral liquid and Glimepiride can regulate the blood lipid, decrease the TG, TC, LDL-c level, and increase the HDL-c level.2. Wu-Shen oral liquid and Glimepiride can regulate blood sugar metabolism, improve insulin resistance.Have the sigbificantly difference than model group (p< 0.05).3. There is no difference of regulating the balance of ET/NO between the Wu-Shen oral liquid and Isoket4. Wu-Shen oral liquid can adjust fat cells factor function and restrain the inflammatory response vessels to protect endothelial. Isoket group and Glimepiride group also have a similar effect.5. Wu-Shen oral liquid have the remarkable effect on preventing the acute myocardial ischemic induced by Pituitrin.6. Wu-Shen oral liquid extinct atherosclerosis lipid plaque. Have the significantly difference than model group(p<0.05)Conclusion: Wu-Shen oral liquid canremission angina pectoris.Its mechanism perhaps is by regulating the blood lipid, adjusting sugar metabolism, inhibiting vascular inflammatory reaction and Wu-Shen oral liquid canremission angina pectoris. its mechanism perhaps is by regulating the blood lipid, adjusting sugar metabolism, inhibiting vascular inflammatory reaction and protecting endothelial function to protect myocardial tissue.