Serum Cholinesterase, Platelet, Liver Fibrosis HBV Infection In Various Stages Of Clinical Significance

Objective: To study chronic hepatitis B, hepatitis B liver cirrhosis, decompensated cirrhosis, and acute hepatitis, the relationship among liver fibrosis serum cholinesterase and platelets.Methods: Retrospective study of 262 cases (including acute hepatitis, chronic hepatitis B, hepatitis B liver cirrhosis and decompensated liver cirrhosis) in patients with the information. Analysis of liver fibrosis: laminin (LN),â…¢procollagen (PCâ…¢), hyaluronic acid (HA),â…£collagen (â…£C); liver function: cholinesterase (CHE); blood Index: platelet count (PLT). And results in chronic hepatitis B, hepatitis B liver cirrhosis, decompensated cirrhosis, acute hepatitis B were compared between the different organizations.Results: 1. HA in patients with chronic hepatitis B, hepatitis B liver cirrhosis, decompensated cirrhosis gradually increased in decompensated liver cirrhosis and chronic hepatitis B. There were significant differences between the (P <0.001). HA levels in acute hepatitis B compared with other groups no significant difference (P> 0.05). 2. PCâ…¢in hepatitis B liver cirrhosis was the highest, followed by chronic hepatitis B and acute hepatitis, decompensated liver cirrhosis group was the lowest. In hepatitis B liver cirrhosis group, and decompensated liver cirrhosis were significantly different between groups (P <0.05). Hepatitis B liver cirrhosis in chronic hepatitis B group and significantly different group (P <0.05). 3.â…£collagen in each group were increased to varying degrees, but each group no significant difference between (P> 0.05). 4. LN in decompensated liver cirrhosis group was higher than the other three groups, but the other three groups with no significant difference between the two groups (P> 0.05). 5. CHE in decompensated liver cirrhosis was significantly lower, and with the other three groups was statistically significant difference between (P <0.005). 6. PLT in hepatitis B liver cirrhosis detected close to the normal value off the assembly line, and chronic hepatitis B group were significantly different (P <0.01), and acute hepatitis B group were significantly different (P <0.005 ); PLT in decompensated liver cirrhosis was significantly lower than normal test values, and chronic hepatitis B group were significantly different (P <0.005), and acute hepatitis B group were significantly different (P < 0.005); PLT in acute hepatitis B and chronic hepatitis B group were significantly different (P <0.01).Conclusion: 1. with the HA levels, gradually increasing the degree of liver fibrosis. 2. PCâ…¢suggest active liver fibrosis, there does not reflect liver fibrosis. 3.â…£collagen suggest hepatic fibrosis, but does not reflect the degree of hepatic fibrosis. 4. LN judging the degree of liver fibrosis than HA, PCâ…¢,â…£collagen sensitive. 5. CHE may have long-term decreased the incidence of cirrhosis. 6. platelets can be used to determine the degree of liver fibrosis is a simple, more accurate secondary method.