Effects Of Allopurinol On Cardiac Function In Patients With Diastolic Heart Failure

Objective:To observe the effects of allopurinol on cardiac function in patients with diastolic heart failure.Methods 50 patients with diastolic heart failure were randomly divided into two groups:group one (n=26) was received allopurinol 0.3g/d plus routine therapy (allopurinol group), and group two (n=24) received routine therapy (routine group) only. Plasma B-type natriuretic peptide(NT-proBNP), malondialdehyde and nitric oxide level were assayed respectively on three time points-before therapy and 15th or 30th day therapy. In addition, left ventricular ejection fraction(LVEF) and left ventricular filling index E/E' were measured by echocardiographic assessment of the tissue doppler. The E/E'is the ratio of the peak early mitral valve flow velocity to the peak early diastolic mitral annual velocity.Resultsâ‘ The E/E' and level of plasma NT-proBNP or malondialdehyde were significantly decreased and the plasma nitric oxide level was significantly increased on 15th and 30th day therapy with allopuronol compared with non-therapy.â‘¡There were insignificant difference between allopurinol and routine group on 15th day therapy, but significantly decreased E/E', plasma NT-proBNP and plasma malondialdehyde and significantly increased plasma nitric oxide were observed.â‘¢While significantly decreased E/E'and level of plasma NT-proBNP or malondialdehyde, increased plasma nitric oxide level were observed on 30th day.Conclusions:Allopurinol could improve the cardiac function in patients with diastolic heart failure. This effect may be associated with inhibite oxidative stress and improve the vascular endothelial function so as to contribute to left ventricular remodeling.