The Distribution Of HBV Genotype Between HBV Infection-associated Hepatocellular Carcinoma And HBV Infection With Different Immune Status In Northern Region Of Guangxi

Objective:To investigate the distribution about HBV genotype in HBV infection-associated hepatocellular carcinoma and Chronic HBV infection with different immune status in Northern region of Guangxi.Methods:46 patients with HBV infection-associated HCC and 90 patients with Chronic HBV infection with different immune status in Northern of Guangxi Zhuang Autonomous Region were randomly chosen for this study. HBV genotypes were determined by real-time fluorescence quantitative polymerase chain reaction. The laboratory and pathological information of these patients, were obtained by reviewing of the clinical documentation of patients. Statistical software SPSS17.0 was used for statistical analyses.A P value less than 0.05 was considered statistically significant.Results:Genotype B accounted for 77.8% in the chronic HBV infected patients, Genotype C accounted for 18.9%, 3 patients did not analyze the genotype (3.3% ); Genotype B accounted for 78.3% in the chronic HBV infected patients, Genotype C accounted for 21.7%;there were no significant difference between HBV infection and HCC about HBV genotype(P>0.05) ;the distribution of genotypes was no difference between in different immune status in chronic HBV infection(P>0.05),genotypes and immune status had no significant association.There were no significant differences about the Clinical data in chronic HBV infected patients with Genotype B and C(P>0.05), however, the replication levels of HBV-DNA have significant distinction in HCC patients with Genotype B and C(P<0.01);The comparation about laboratory data such as ALT,AST,TBIL,ALB,ages have significant difference between Chronic HBV infection and HCC(P<0.05),but Sex has no difference (P>0.05). Conclusion:Genotype B was dominant in the Patients with chronic HBV infection and HBV infection-associated HCC in Northern of Guangxi Zhuang Autonomous Region, the distribution of genotypes has no difference between HCC and Chronic HBV infection with different immune status,Genotype C have higher viral replication levels of HBV-DNA.