| Objective:Investigate the enhancement of the Bioactive glass repair rat femoral condyle of lacunar defects.Methods: Use the Femoral condyle lacunar defect model of established SD rats (weighing about 350 grams), divided the rat into experimental group(bone defects implanted Bioactive glass),the control group (bone defects implanted with autogenous bone) and the blank control group (didn't implanted any Material in bone defects)depending on whether implant material and the difference of the implant material. Experimental indicators: (1) The curative effect of Bioactive glass repair bone defect;(2) The bone defect curative effect Comparison of Bioactive glass and self-repair;(3) self-repair capacity of rats of the femoral condyle defect 2 mm in diameter;(4)the experimental group and control group respectively after 2 weeks, 6 weeks, 10 weeks, the general line of observation of the femoral condyle specimen observation, histological observation and scanning electron microscopy. The control group after 2 weeks, 6 weeks, 10 weeks of the general line of observation of the femoral condyle specimen observation, histological observation.Results: Both the Bioactive glass and autogenous bone can repair the bone defect, the result between the two groups has no significant difference both in the radiological examination and the histologically observation for the mass of the new bone at 6 weeks and 10 weeks. We found that the implanted material and the normal bone have clear boundaries in 2 weeds; who will blur in 6 weeks; the Bioactive glass will disappeared and the new bone will more mature ,the boundaries will vanished at 10 weeds through the scanning electron microscope in the experimental group. While the bone of host and bone of impplantation have clear boundaries in 2 weeks; the new bone will grow into bone of impplantation all around; the combined areas will fiber calcification and disappear in 10 weeks in the Control group. However the blank team will appear the histogenesis of fibrous scar and has a few osteosis in the bone defect. So the experimental group and control group was statistically significant.Conclusion: (1) Bioactive glass can replace autogenous bone repair bone defect; (2) the femoral condyle defect within 2 mm in diameter on rats has the self-repair capacity. Objective:Analysis of effect on early implantation of Bioactive glass cure clavicle fractures.Methods: From July 2008 to January 2010, selected 45 medical records of clavicle fractures cases randomly from Hebei united University Affiliated Orthopaedic hospital Medical Records Department,all these patients were treated with open reduction and internal fixation with bone grafting or implantation of Bioactive glass. All the patients were randomly divided into two groups,the former group include 27 cases were implanted with Bioactive glass,while the other group include 18 cases were implanted with autologous bone.Results: All patients received follow-up 6 to 12 months, an average of 8 months, until the fracture healed。The average healing time of fracture in Bioactive glass group average of 12.6 weeks, no delayed union and nonunion. The healing time of autologous bone was 12.0 weeks, no delayed union and nonunion.Assessed curative effect of patients with fracture healing time and functional recovery of shoulder after surgery, after 12 weeks the excellent ratio of bioactive glass group was 96% and the autograft group was 100%. The two groups were not statistically significant difference (P >0.05).Conclusion: Bioactive glass and autologous bone can early implant with internal fixation to treatment fracture, can accelerate fracture healing, reduce the incidence of delayed union and nonunion. |
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