Small Cell Lung Cancer Were Analyzed Retrospectively And Research Of Prognostic Factors

Objective:Analyze 65 patients with small cell lung cancer pathology. Treatment and follow-up data in 3 and a half years in Central Hospital of Jilin City Central Hospital. Analyze its prognostic factors,To improve the diagnosis and treatment of small cell lung cancer reference information.Methods:Collected cases with clinical and follow—up data,that it Diagnosed small cell lung cancer patients in the Jilin City Central Hospital for treatment in March 2005 -September 2008. All data using SPSS for windows 16.0 statistical softaare for statistical analysis.Result:①The survey of 65 patients with small cell lung cancer patients,51 male patients,14 female patients:Aged 39-81 years, mean age 55.9±1.3 years.48 smoking patients,17 patients with non-smokers.Chemotherapy and surgery in which 2 patients, Receiving radiotherapy did not receive surgical treatment of 5 patients, Patients received chemotherapy alone 38 people. After treatment, patients who achieved CR 7 people, PR 46 people, SD 8 people,PD 4 people.②25 people were high CEA value, took up 55.6% before treatment,56 people were high NSE value, took up 86.2%,12 people were high LDH value, took up 18.5%,6 people were high APL value, took up 9.3%,9 people were low blood Na value, took up 13.8%,,2 people were high LDH value, took up 3.1%, One of the most significant increase in SE values, the highest proportion.8 people were high CEA value, took up 12.4% after treatment, 18 people were high NSE value, took up 27.7%,4 people were high LDH value, took up 6.2%,2 people were high APL value, took up 3.1%,2 people were low blood Na value, took up 3.1%,,1 people were high LDH value, took up 1.6%.③Before and after treatment in patients with small cell lung cancer paired samples T test indicators test (Paired-Samples T Test), The results show that Laboratory indicators before and after treatment in the CEA,NSE, CDH, blood Na, ALP were significantly different, CK-MB was no significant difference.④The survey of 65 patients with small cell lung cancer patients, Before treatment, patients with normal CEA, 1,2,3-year survival was 67.5%,405,17.5%:Patients were elevated 60%,36%, 12%;PatIents with normal NSE,1,2,3-year survival was 77.8%, 44.4%, 11.1%;increase of patients were 73.2%,32.1%, 12.5% Patients with normal blood Na,1,2,3-year survival was 66.1%, 41.5%,15.1%:reduce the patients were 58.3%,33.3%,8.3%;Patients wich normal ALP,1,2,3 years survival was 66.7%,40.7%, 14.8% increase the patients werE 63.6%,36.4%,9%; Patients with normal LDH, 1,2,3-years survival was 75%,35.7%,14.3%:increase of patients were 55.6%,33.3%,22.2%;Patients wich normal CK-MB,1, 2,3-year survival was 76.2%,36.5%,17.5%;increase of patients were 0%,0%,0%.⑤By Kaplan.Meier method,Log-rank log—rank test method for single factor analysis, The results showed that age, gender, stage,treatment, laboratory indicators of small-cell lung cancer prognostic factors.Conciusion:①Interms of specificity or sensitivity for diagnosis, NSE were significantly better than CEA,LDH, a marker of choice for diagnosis of SCLC.②Elevated tumor markers before chemotherapy, after chemotherapy decreased, indicating that the chemotherapy:Decreased slightly after chemotherapy, then re-elevated,suggesting that resistance to chemotherapy is invalid or chemotherapy:Decreased after chemotherapy, and then significantly increased over time,suggesting tumor recurrence or metastasis.This prompted early clinical symptoms are often before a few months. After treatment, cancer patients,tumor marker rise and fall with the efficacy and prognosis of patients with good correlation.③CK-MB can be used as another indicator of the prognosis is extremely poor.