| Objective: To study the changes of interleukin-1 (IL-1) and erythropoietin (EPO) levels in patients with anemia of chronic disease of rtheumatoid arthritis (RA)Methods; To use the case-control way as the research method,and meet diagnosis of rtheumatoid arthritis patients(aged 25-75 years)as the research object.Using the 30 normal health patients as the control group, collecting all the patients and healthy controls serum,and cassetting a detailed notes with clinical data of patients. According to patient blood and erythrocyte sedimentation rate and serum ferritin test cases for the classification of rheumatoid arthritis collected (ACD group with 20 people, with IDA group of 20 people, no anemia group 30 people). Using ELISA method to discover the IL-1 and the level of the EPO.To anylize the difference of three groups,and to compeared with control group(30 cases). To discuss the relationship between the levels of IL-1 and the degree of anemia..Result:The level of IL-1 in RA patients with ACD were singnificantly higher than the healthy controls group and those RA group without anemia(P<0.01).The level of EPO in RA-ACD group were singnificantly higher than those RA group without anemia and the control group (P<0.05). The level of RA-ACD group were singnificantly lower than those RA group without anemia group (P<0.01), The level of RA-ACD group were singnificantly higher than the RA-IDA group (P<0.01) and have no significant difference with RA group without anemia(P>0.05). IL-1 and ESR was positively correlated (r=0.67, P<0.05); with each group ferritin was negatively correlated (r=a 0.40, P<0.05); with RA with ACD anemia The Hb was negatively correlated (r=a 0.57, P<0.05); and EPO was no significant correlation (r=0.15, P> 0.05).Conclusion:IL-1 level is closely related to genesis and development of RA-ACD;EPO is relatively deficient in RA-ACD group,IL-1 might be related to iron metabolism and the generation of EPO. |
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